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TP53BP2 and TCL1A
Data Source:
BioGRID
(two hybrid)
TP53BP2
TCL1A
Description
tumor protein p53 binding protein 2
TCL1 family AKT coactivator A
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Cell Junction
Perinuclear Region Of Cytoplasm
Nucleoplasm
Endoplasmic Reticulum
Cytosol
Protein-containing Complex
Molecular Function
P53 Binding
Protein Binding
SH3 Domain Binding
Identical Protein Binding
NF-kappaB Binding
Protein Binding
Protein Kinase Binding
Identical Protein Binding
Protein Serine/threonine Kinase Activator Activity
Biological Process
Cell Cycle
Signal Transduction
Regulation Of Apoptotic Process
Negative Regulation Of Cell Cycle
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Execution Phase Of Apoptosis
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Neuron Death
Regulation Of Signal Transduction By P53 Class Mediator
Multicellular Organism Development
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Mitochondrial Membrane Potential
Positive Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Apoptotic Process
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS
Triptolide cytotoxicity (
26121980
)
Adverse response to aromatase inhibitors (
20876420
)
Mosaic loss of chromosome Y (
27064253
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
28346444
31624269
)
Plateletcrit (
32888494
)
Refractive error (
32231278
)
Interacting Genes
122 interacting genes:
ADAMTS12
APP
APPL1
ARHGEF6
ATPAF2
ATXN7
AXIN1
BAG3
BAIAP2
BCAS2
BCL2
BCL2L1
CCDC13
CCDC57
CCDC85A
CCDC92
CDC5L
CEP55
CEP95
CGN
CRK
CSNK2B
CWF19L2
DCUN1D1
DDX6
DIRAS1
EEF1A1
EFHC1
ELOA
GCC1
GEM
GFAP
GOLGA1
GPS2
GRB2
H2BC4
H2BC9
HHEX
HIF1AN
HNRNPUL1
HSF2BP
INSYN2A
IQUB
KDM1A
KIF5A
LHX4
LMNB1
LMNB2
LMO4
MAGI1
MAPK8IP2
MOS
MRPL20
MTMR14
MTURN
NAE1
NDC80
NEDD4
NFKB1
NHSL2
NUTM1
OTUB2
PHF1
PIBF1
PLEKHF2
PLEKHN1
PLK1
POLR2L
PPHLN1
PPP1CA
PPP1CB
PPP1CC
PRAM1
PRKAB2
PRPF31
PTN
RALBP1
RASAL3
RASSF10
RASSF8
RELA
RGMA
RXRB
SCNM1
SETD5
SH3KBP1
SH3RF1
SHTN1
SIAH1
SIAH2
SUMO2
SUMO3
TANK
TBC1D22B
TCL1A
TP53
TRAF4
TROAP
TSGA10
TXLNA
TYK2
UBASH3A
UBASH3B
UBE3A
UBTD1
UNC119
USP4
UTP14A
WWP1
WWP2
YAP1
YES1
YOD1
YWHAG
YWHAQ
ZBTB4
ZFP91
ZGPAT
ZNF26
ZNF438
ZNF552
ZNF575
38 interacting genes:
AKT1
AKT2
AKT3
ATM
CADPS
CALCOCO2
CARD9
CASP8AP2
CCDC13
CEP55
DDIT4L
DNMT3A
FLACC1
GOLGA2
H2AW
INCA1
LNX1
LNX2
LSM3
NFKBIA
NFKBID
NIF3L1
NTAQ1
PPP1R13B
PRTFDC1
REL
TAX1BP1
TCF4
TEPSIN
TNKS
TP53BP2
TRAF1
TRAF2
TRMT61A
TTC33
TXLNA
TXLNB
WDR47
Entrez ID
7159
8115
HPRD ID
11803
01744
Ensembl ID
ENSG00000143514
ENSG00000100721
Uniprot IDs
Q13625
A0A024R6G5
P56279
PDB IDs
1YCS
2UWQ
4A63
4IRV
6GHM
6HKP
1JSG
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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