YWHAQ and BAD

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology, two hybrid)
HPRD (two hybrid, in vitro, in vivo)

		YWHAQ	BAD
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	BCL2 associated agonist of cell death
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Focal Adhesion Membrane Protein-containing Complex Synapse Extracellular Exosome	Mitochondrion Mitochondrial Outer Membrane Cytosol
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Identical Protein Binding Ion Channel Binding Protein N-terminus Binding 14-3-3 Protein Binding	Protein Binding Phospholipid Binding Lipid Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Protein Kinase Binding Protein Phosphatase Binding Protein Phosphatase 2B Binding Protein Kinase B Binding 14-3-3 Protein Binding
	Biological Process	Protein Targeting Small GTPase Mediated Signal Transduction Substantia Nigra Development Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transcription, DNA-templated Membrane Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Release Of Cytochrome C From Mitochondria Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Glucose Catabolic Process Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Spermatogenesis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Glucose Positive Regulation Of Autophagy Positive Regulation Of Mitochondrial Membrane Potential Suppression By Virus Of Host Apoptotic Process Cytokine-mediated Signaling Pathway Cerebral Cortex Development Positive Regulation Of Insulin Secretion Response To Estradiol Response To Progesterone Positive Regulation Of Glucokinase Activity Response To Testosterone Response To Oleic Acid Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Drug Response To Hydrogen Peroxide Glucose Homeostasis Positive Regulation Of Apoptotic Process Response To Amino Acid Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Type B Pancreatic Cell Proliferation Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Proteolysis ADP Metabolic Process ATP Metabolic Process Regulation Of Mitochondrial Membrane Permeability Pore Complex Assembly Positive Regulation Of Epithelial Cell Proliferation Response To Glucocorticoid Response To Calcium Ion Positive Regulation Of Apoptotic Process By Virus Cellular Response To Chromate Cellular Response To Mechanical Stimulus Cellular Response To Nicotine Cellular Response To Lipid Cellular Response To Hypoxia Positive Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Neuron Death Response To Benzene Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Granulosa Cell Apoptotic Process Positive Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors	Activation of BAD and translocation to mitochondria Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK AKT phosphorylates targets in the cytosol Constitutive Signaling by AKT1 E17K in Cancer
Drugs		Phenethyl Isothiocyanate	Navitoclax
Diseases
GWAS		Heart rate variability traits ( 22174390) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933)	Crohn's disease ( 28067908) Heel bone mineral density ( 30598549) Platelet count ( 22423221) Sarcoidosis ( 22837380) Vitiligo ( 27723757)
Interacting Genes		240 interacting genes: AARS2 ABL1 ACSL4 ADRB2 AGTR1 AHCY AKT1S1 ANXA1 ANXA2 APC AR ARHGAP10 ARHGEF16 ARHGEF2 ATP5F1A BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDK17 CDK18 CDKN1A CDKN1B CEP170 CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EGFR EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 EXO1 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1 H2BC8 H4C14 HADHA HAT1 HAX1 HDAC4 HDAC5 HDAC7 HNRNPC HNRNPF HNRNPH1 HNRNPK HSPA1A HSPA8 HSPB1 HUS1 IARS2 ING1 IQGAP1 IRS2 ITGB4 ITPRID2 KANK1 KCNK15 KCNK3 KCNK9 KIF1C KIF23 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LMO7 LYST MAGOH MAP3K3 MAP3K5 MARK2 MARK3 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPN1 PAK4 PANK1 PCM1 PDCD6 PDE3A PDE3B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C2B PIK3C3 PIK3CB PKM PPFIBP1 PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 PTPN3 RAF1 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SOCS3 SPR SPTA1 SPTB SRSF3 SSBP1 SSX2IP SUMO2 TCP1 TERT THRA TLN1 TNF TNFAIP3 TP53BP2 TPI1 TPR TRAF6 TRIM25 TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBE2L3 UBQLN4 UCP2 UCP3 ULK4 USP8 VARS1 WDR61 WDR77 WEE1 WTAP WWC2 WWP1 YAP1 YWHAE YWHAG ZC3H13 ZHX2	45 interacting genes: ACTN2 AKT1 ARAF BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BRAF CDKN1A CREB3L3 EWSR1 HRK KEAP1 KRT31 MAP2K5 MAPK8 MCL1 PAK1 PAK5 PIM1 PIM2 PIM3 PPP1CA PPP3CA PRDX2 PRKACA PRKCI RAF1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A10 SFN SNCA STEAP3 SUMO2 WASF1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		10971	572
HPRD ID		00886	04409
Ensembl ID		ENSG00000134308	ENSG00000002330
Uniprot IDs		P27348	A0A024R562 Q92934
PDB IDs		2BTP 5IQP 6BCR 6BD2 6BQT 6KZG 6KZH	1G5J
Enriched GO Terms of Interacting Partners?
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