Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
TP53BP2 and CCDC57
Data Source:
BioGRID
(two hybrid)
TP53BP2
CCDC57
Description
tumor protein p53 binding protein 2
coiled-coil domain containing 57
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Cell Junction
Perinuclear Region Of Cytoplasm
Centrosome
Centriole
Spindle Microtubule
Centriolar Satellite
Molecular Function
P53 Binding
Protein Binding
SH3 Domain Binding
Identical Protein Binding
NF-kappaB Binding
Protein Binding
Biological Process
Cell Cycle
Signal Transduction
Regulation Of Apoptotic Process
Negative Regulation Of Cell Cycle
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Execution Phase Of Apoptosis
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Neuron Death
Regulation Of Signal Transduction By P53 Class Mediator
G2/M Transition Of Mitotic Cell Cycle
Microtubule Nucleation
Centriole Replication
Positive Regulation Of Mitotic Cell Cycle
Cilium Assembly
Pathways
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS
Triptolide cytotoxicity (
26121980
)
Blood metabolite levels (
24816252
)
Blood urea nitrogen levels (
31152163
)
Proteinuria and chronic kidney disease (
26420894
)
Refractive error (
32231278
)
Interacting Genes
122 interacting genes:
ADAMTS12
APP
APPL1
ARHGEF6
ATPAF2
ATXN7
AXIN1
BAG3
BAIAP2
BCAS2
BCL2
BCL2L1
CCDC13
CCDC57
CCDC85A
CCDC92
CDC5L
CEP55
CEP95
CGN
CRK
CSNK2B
CWF19L2
DCUN1D1
DDX6
DIRAS1
EEF1A1
EFHC1
ELOA
GCC1
GEM
GFAP
GOLGA1
GPS2
GRB2
H2BC4
H2BC9
HHEX
HIF1AN
HNRNPUL1
HSF2BP
INSYN2A
IQUB
KDM1A
KIF5A
LHX4
LMNB1
LMNB2
LMO4
MAGI1
MAPK8IP2
MOS
MRPL20
MTMR14
MTURN
NAE1
NDC80
NEDD4
NFKB1
NHSL2
NUTM1
OTUB2
PHF1
PIBF1
PLEKHF2
PLEKHN1
PLK1
POLR2L
PPHLN1
PPP1CA
PPP1CB
PPP1CC
PRAM1
PRKAB2
PRPF31
PTN
RALBP1
RASAL3
RASSF10
RASSF8
RELA
RGMA
RXRB
SCNM1
SETD5
SH3KBP1
SH3RF1
SHTN1
SIAH1
SIAH2
SUMO2
SUMO3
TANK
TBC1D22B
TCL1A
TP53
TRAF4
TROAP
TSGA10
TXLNA
TYK2
UBASH3A
UBASH3B
UBE3A
UBTD1
UNC119
USP4
UTP14A
WWP1
WWP2
YAP1
YES1
YOD1
YWHAG
YWHAQ
ZBTB4
ZFP91
ZGPAT
ZNF26
ZNF438
ZNF552
ZNF575
148 interacting genes:
ABI1
ABI2
ABLIM1
AMOTL2
ANKRD23
AQP1
ARID5A
ARL4A
AXIN1
BCAR3
BEX2
C19orf44
C2CD6
C4orf45
C9orf24
CBX8
CBY2
CCDC120
CCDC33
CDC20B
CEP57L1
CFAP53
COIL
CRTC2
CWF19L2
DCLK2
DISC1
DTX2
ECPAS
EFHC2
EIF3D
EIF4G1
ELOA
EMILIN3
ESS2
FAM107A
FAM161A
FAM161B
FAM228A
FAM50B
FAM90A1
FH
FOXD4L1
FTO
GFAP
GIGYF1
GPBP1
GPKOW
GRPEL1
HAUS1
HBA2
HDX
IHO1
IKZF3
INCA1
INTS2
JRK
KANK2
KIAA0408
KLF1
KLF15
KPRP
KRT4
KRT76
KRTAP13-2
KRTAP13-3
LENG1
LINC00526
LZTS1
MAD1L1
MDM1
MFAP1
MT1E
MYOZ3
NAB2
NAPRT
NCOA5
NELFE
NME4
NUMA1
PAK5
PER1
POM121
PPHLN1
PPP1R18
PPP1R32
PRAM1
PRDM6
PROSER3
PRPF18
PRPF31
PRR3
PSMB4
PTCHD3
PTPN7
RAB3IL1
RASD1
RBM48
RDM1
RINT1
RNF6
ROBO3
RUSC1
RXRB
SFI1
SH3KBP1
SHISA6
SIRPA
SLC25A48
SMG9
SNRNP35
SORBS3
SPRY1
SYT6
TBC1D22B
TCP10L
TFIP11
TFPT
TIMM44
TLE5
TMEM100
TNNI1
TP53BP2
TRIM14
TRIM29
TSEN54
TSGA10IP
TSHZ2
TXLNA
USP15
USP2
UTP14C
VPS52
YJU2
ZBTB4
ZC2HC1C
ZFC3H1
ZGPAT
ZMAT2
ZNF417
ZNF436
ZNF474
ZNF552
ZNF648
ZNF655
ZNF688
ZNF835
ZSWIM3
Entrez ID
7159
284001
HPRD ID
11803
14150
Ensembl ID
ENSG00000143514
ENSG00000176155
Uniprot IDs
Q13625
A0A590UJT6
Q2TAC2
PDB IDs
1YCS
2UWQ
4A63
4IRV
6GHM
6HKP
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?