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TP53BP2 and YAP1
Data Source:
BioGRID
(unspecified method)
HPRD
(in vitro, in vivo)
TP53BP2
YAP1
Description
tumor protein p53 binding protein 2
Yes1 associated transcriptional regulator
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Cell Junction
Perinuclear Region Of Cytoplasm
Female Germ Cell Nucleus
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
TEAD-YAP Complex
Molecular Function
P53 Binding
Protein Binding
SH3 Domain Binding
Identical Protein Binding
NF-kappaB Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Protein C-terminus Binding
Proline-rich Region Binding
DNA-binding Transcription Factor Binding
Biological Process
Cell Cycle
Signal Transduction
Regulation Of Apoptotic Process
Negative Regulation Of Cell Cycle
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Execution Phase Of Apoptosis
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Neuron Death
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
Vasculogenesis
Trophectodermal Cell Differentiation
Tissue Homeostasis
Heart Process
Embryonic Heart Tube Morphogenesis
Transcription Initiation From RNA Polymerase II Promoter
Cellular Response To DNA Damage Stimulus
Cell Population Proliferation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Keratinocyte Proliferation
Keratinocyte Differentiation
Negative Regulation Of Epithelial Cell Differentiation
Notochord Development
Response To Progesterone
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Somatic Stem Cell Population Maintenance
Hippo Signaling
Wound Healing
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Development
Lateral Mesoderm Development
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Neurogenesis
Progesterone Receptor Signaling Pathway
Positive Regulation Of Cardiac Muscle Cell Proliferation
Contact Inhibition
Bud Elongation Involved In Lung Branching
Lung Epithelial Cell Differentiation
Intestinal Epithelial Cell Development
Cardiac Muscle Tissue Regeneration
Protein-containing Complex Assembly
Interleukin-6-mediated Signaling Pathway
Cellular Response To Retinoic Acid
Cellular Response To Gamma Radiation
Regulation Of Stem Cell Proliferation
Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Localization To Nucleus
Negative Regulation Of Cilium Assembly
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Stem Cell Population Maintenance
Negative Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of Stem Cell Differentiation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors
Nuclear signaling by ERBB4
Signaling by Hippo
YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX2 regulates osteoblast differentiation
RUNX3 regulates YAP1-mediated transcription
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS
Triptolide cytotoxicity (
26121980
)
Cleft palate (
27018472
)
Colorectal cancer or advanced adenoma (
30510241
)
Heel bone mineral density (
30598549
)
Migraine (
27322543
)
Offspring birth weight (
31043758
)
Polycystic ovary syndrome (
22885925
30566500
26416764
)
Prostate cancer (
23535732
)
Pubertal anthropometrics (
23449627
)
Pulse pressure (
30224653
30578418
)
Reticulocyte count (
32888494
)
Whole-brain volume (Alzheimer's disease interaction) (
21116278
)
Interacting Genes
122 interacting genes:
ADAMTS12
APP
APPL1
ARHGEF6
ATPAF2
ATXN7
AXIN1
BAG3
BAIAP2
BCAS2
BCL2
BCL2L1
CCDC13
CCDC57
CCDC85A
CCDC92
CDC5L
CEP55
CEP95
CGN
CRK
CSNK2B
CWF19L2
DCUN1D1
DDX6
DIRAS1
EEF1A1
EFHC1
ELOA
GCC1
GEM
GFAP
GOLGA1
GPS2
GRB2
H2BC4
H2BC9
HHEX
HIF1AN
HNRNPUL1
HSF2BP
INSYN2A
IQUB
KDM1A
KIF5A
LHX4
LMNB1
LMNB2
LMO4
MAGI1
MAPK8IP2
MOS
MRPL20
MTMR14
MTURN
NAE1
NDC80
NEDD4
NFKB1
NHSL2
NUTM1
OTUB2
PHF1
PIBF1
PLEKHF2
PLEKHN1
PLK1
POLR2L
PPHLN1
PPP1CA
PPP1CB
PPP1CC
PRAM1
PRKAB2
PRPF31
PTN
RALBP1
RASAL3
RASSF10
RASSF8
RELA
RGMA
RXRB
SCNM1
SETD5
SH3KBP1
SH3RF1
SHTN1
SIAH1
SIAH2
SUMO2
SUMO3
TANK
TBC1D22B
TCL1A
TP53
TRAF4
TROAP
TSGA10
TXLNA
TYK2
UBASH3A
UBASH3B
UBE3A
UBTD1
UNC119
USP4
UTP14A
WWP1
WWP2
YAP1
YES1
YOD1
YWHAG
YWHAQ
ZBTB4
ZFP91
ZGPAT
ZNF26
ZNF438
ZNF552
ZNF575
33 interacting genes:
ABL1
AKT1
ENAH
ERBB4
GAS5
HNRNPU
KIF5A
LINC00839
NFE2
OTUD1
PRRG2
PTCH1
PTEN
PTPN21
RUNX1
RUNX2
RUNX3
SCAMP3
SLC9A3R1
SMAD1
SMAD7
SUMO3
TEAD1
TEAD2
TEAD3
TEAD4
TP53BP2
TP73
WBP1
WBP2
YWHAG
YWHAQ
YWHAZ
Entrez ID
7159
10413
HPRD ID
11803
09424
Ensembl ID
ENSG00000143514
ENSG00000137693
Uniprot IDs
Q13625
A0A024R3E4
K0KVU2
P46937
Q86T74
PDB IDs
1YCS
2UWQ
4A63
4IRV
6GHM
6HKP
1JMQ
1K5R
1K9Q
1K9R
2LAW
2LAX
2LAY
2LTV
2LTW
3KYS
3MHR
4RE1
4REX
5OAQ
5YDX
5YDY
6G6X
6G8I
6G8J
6G8K
6G8L
6G8P
6G8Q
6GE3
6GE4
6GE5
6GE6
6GEC
6GEE
6GEG
6GEI
6GEK
6HIK
6HIL
6Q2X
Enriched GO Terms of Interacting Partners
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