YWHAQ and SLC8A3

Data Source:
HPRD (in vitro)

		YWHAQ	SLC8A3
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	solute carrier family 8 member A3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Focal Adhesion Membrane Protein-containing Complex Synapse Extracellular Exosome	Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Microtubule Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Membrane Sarcoplasm Axon Dendrite Intrinsic Component Of Plasma Membrane Neuromuscular Junction Sarcolemma Neuronal Cell Body Dendritic Spine Perikaryon Axon Terminus Synapse Perinuclear Region Of Cytoplasm Postsynapse Integral Component Of Postsynaptic Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Identical Protein Binding Ion Channel Binding Protein N-terminus Binding 14-3-3 Protein Binding	Calcium:sodium Antiporter Activity Calmodulin Binding Cation:cation Antiporter Activity Metal Ion Binding Ion Antiporter Activity Involved In Regulation Of Postsynaptic Membrane Potential Calcium:cation Antiporter Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
	Biological Process	Protein Targeting Small GTPase Mediated Signal Transduction Substantia Nigra Development Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transcription, DNA-templated Membrane Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Hematopoietic Progenitor Cell Differentiation Ion Transport Mitochondrial Calcium Ion Transmembrane Transport Cellular Calcium Ion Homeostasis Cell Communication Learning Or Memory Learning Memory Regulation Of Skeletal Muscle Contraction Telencephalon Development Metal Ion Transport Sodium Ion Transmembrane Transport Myelination Oligodendrocyte Differentiation Synapse Organization Mitochondrial Calcium Ion Homeostasis Long-term Synaptic Potentiation Calcium Ion Transmembrane Transport Cellular Response To CAMP Cellular Response To Hypoxia Negative Regulation Of Protein Serine/threonine Kinase Activity Calcium Ion Import Across Plasma Membrane Modulation Of Excitatory Postsynaptic Potential Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Cardiac Conduction Calcium Ion Export Across Plasma Membrane
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors	Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis Mitochondrial calcium ion transport
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Heart rate variability traits ( 22174390) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933)	Bipolar disorder ( 31043756) Corneal curvature ( 22969067) Cystic fibrosis severity ( 21602797) Daytime sleep phenotypes ( 27126917) Metabolite levels ( 23823483)
Interacting Genes		240 interacting genes: AARS2 ABL1 ACSL4 ADRB2 AGTR1 AHCY AKT1S1 ANXA1 ANXA2 APC AR ARHGAP10 ARHGEF16 ARHGEF2 ATP5F1A BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDK17 CDK18 CDKN1A CDKN1B CEP170 CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EGFR EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 EXO1 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1 H2BC8 H4C14 HADHA HAT1 HAX1 HDAC4 HDAC5 HDAC7 HNRNPC HNRNPF HNRNPH1 HNRNPK HSPA1A HSPA8 HSPB1 HUS1 IARS2 ING1 IQGAP1 IRS2 ITGB4 ITPRID2 KANK1 KCNK15 KCNK3 KCNK9 KIF1C KIF23 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LMO7 LYST MAGOH MAP3K3 MAP3K5 MARK2 MARK3 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPN1 PAK4 PANK1 PCM1 PDCD6 PDE3A PDE3B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C2B PIK3C3 PIK3CB PKM PPFIBP1 PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 PTPN3 RAF1 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SOCS3 SPR SPTA1 SPTB SRSF3 SSBP1 SSX2IP SUMO2 TCP1 TERT THRA TLN1 TNF TNFAIP3 TP53BP2 TPI1 TPR TRAF6 TRIM25 TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBE2L3 UBQLN4 UCP2 UCP3 ULK4 USP8 VARS1 WDR61 WDR77 WEE1 WTAP WWC2 WWP1 YAP1 YWHAE YWHAG ZC3H13 ZHX2	5 interacting genes: GJA8 PPP3CB YWHAB YWHAE YWHAQ
Entrez ID		10971	6547
HPRD ID		00886	09723
Ensembl ID		ENSG00000134308	ENSG00000100678
Uniprot IDs		P27348	B3KU59 P57103
PDB IDs		2BTP 5IQP 6BCR 6BD2 6BQT 6KZG 6KZH
Enriched GO Terms of Interacting Partners?
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