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YWHAQ and FGR
Data Source:
HPRD
(in vitro)
YWHAQ
FGR
Description
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
FGR proto-oncogene, Src family tyrosine kinase
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Cytosol
Focal Adhesion
Membrane
Protein-containing Complex
Synapse
Extracellular Exosome
Extracellular Region
Mitochondrial Inner Membrane
Mitochondrial Intermembrane Space
Cytosol
Cytoskeleton
Plasma Membrane
Actin Cytoskeleton
Aggresome
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Ruffle Membrane
Secretory Granule Lumen
Extracellular Exosome
Molecular Function
Protein Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Identical Protein Binding
Ion Channel Binding
Protein N-terminus Binding
14-3-3 Protein Binding
Phosphotyrosine Residue Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Protein Kinase Binding
Immunoglobulin Receptor Binding
Fc-gamma Receptor I Complex Binding
Biological Process
Protein Targeting
Small GTPase Mediated Signal Transduction
Substantia Nigra Development
Negative Regulation Of Ion Transmembrane Transport
Negative Regulation Of Transcription, DNA-templated
Membrane Organization
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Cytokine Production
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Integrin-mediated Signaling Pathway
Regulation Of Cell Shape
Response To Virus
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cell Differentiation
Bone Mineralization
Positive Regulation Of Cell Migration
Negative Regulation Of Natural Killer Cell Activation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Mast Cell Degranulation
Neutrophil Degranulation
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Regulation Of Innate Immune Response
Regulation Of Protein Kinase Activity
Protein Autophosphorylation
Skeletal System Morphogenesis
Regulation Of Phagocytosis
Defense Response To Gram-positive Bacterium
Pathways
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Regulation of localization of FOXO transcription factors
FCGR activation
Platelet sensitization by LDL
Neutrophil degranulation
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Drugs
Phenethyl Isothiocyanate
Dasatinib
Fostamatinib
Zanubrutinib
Diseases
GWAS
Heart rate variability traits (
22174390
)
Non-response to selective serotonin reuptake inhibitors and depression (
27622933
)
Body mass index (
28892062
)
Systolic blood pressure (
30224653
)
Interacting Genes
240 interacting genes:
AARS2
ABL1
ACSL4
ADRB2
AGTR1
AHCY
AKT1S1
ANXA1
ANXA2
APC
AR
ARHGAP10
ARHGEF16
ARHGEF2
ATP5F1A
BAD
BAX
BCAP31
BCR
BRAF
CABIN1
CAPN3
CBL
CBLL1
CCDC125
CDC25A
CDC25B
CDC25C
CDC5L
CDK11B
CDK14
CDK16
CDK17
CDK18
CDKN1A
CDKN1B
CEP170
CFL1
CHAF1A
CKM
CLTC
COPS4
CSE1L
CSNK1A1
CSNK2A1
CTPS1
DAB2IP
DCPS
DDX1
DDX3X
DHX9
DISC1
DNMT1
DYNC1H1
E2F1
EFNB1
EGFR
EIF4A3
ENO1
EPB41
EPB41L1
EPB41L3
ESR1
ESR2
EXO1
FASN
FBLN1
FGR
FSCN1
FSHR
FXYD1
GAPDH
GCN1
H2BC8
H4C14
HADHA
HAT1
HAX1
HDAC4
HDAC5
HDAC7
HNRNPC
HNRNPF
HNRNPH1
HNRNPK
HSPA1A
HSPA8
HSPB1
HUS1
IARS2
ING1
IQGAP1
IRS2
ITGB4
ITPRID2
KANK1
KCNK15
KCNK3
KCNK9
KIF1C
KIF23
KIF5B
KLC2
KLC3
KRT1
KRT9
LARP1
LARS2
LDHA
LIMA1
LMNA
LMNB1
LMO7
LYST
MAGOH
MAP3K3
MAP3K5
MARK2
MARK3
MCM3
MDM4
MED1
MEF2D
MPL
MPRIP
MRPS27
MST1R
MTNR1B
MTOR
MYCBP2
NADK
NCL
NCOA1
NCOA3
NDE1
NFATC1
NFATC2
NFATC4
NFKB1
NIF3L1
NME7
NOLC1
NUMA1
PABPN1
PAK4
PANK1
PCM1
PDCD6
PDE3A
PDE3B
PDK1
PDPK1
PDXK
PFKFB2
PFKL
PFN1
PGK1
PHLDB2
PI4KB
PIK3C2B
PIK3C3
PIK3CB
PKM
PPFIBP1
PRDX1
PRKCQ
PRKCZ
PRKD1
PRKDC
PRMT5
PSME3
PTPN3
RAF1
RAI14
RCOR3
REM1
RFC1
RGS3
RGS7
RNASE2
RPL10A
RPL15
RPL19
RPL7
RPLP0
RPLP2
RPS3
RUVBL2
SAMSN1
SH3BP2
SLC27A2
SLC8A1
SLC8A2
SLC8A3
SMAD9
SNRPE
SOCS3
SPR
SPTA1
SPTB
SRSF3
SSBP1
SSX2IP
SUMO2
TCP1
TERT
THRA
TLN1
TNF
TNFAIP3
TP53BP2
TPI1
TPR
TRAF6
TRIM25
TRIM28
TRIM42
TSC1
TSC2
TUBA1A
TUBA3C
TUBB
UBE2L3
UBQLN4
UCP2
UCP3
ULK4
USP8
VARS1
WDR61
WDR77
WEE1
WTAP
WWC2
WWP1
YAP1
YWHAE
YWHAG
ZC3H13
ZHX2
30 interacting genes:
AR
ARRB1
CBL
CCR3
CSK
DAB2
DOK1
EGFR
ERBB2
ERBB3
ERBB4
FASLG
HCLS1
IKBKG
INPP5D
KHDRBS1
KIT
MET
NR1I2
PTK2
SKAP2
SLAMF1
SMURF1
SNCA
SRC
STAT3
SYK
VDR
WAS
YWHAQ
Entrez ID
10971
2268
HPRD ID
00886
01288
Ensembl ID
ENSG00000134308
ENSG00000000938
Uniprot IDs
P27348
P09769
P78453
PDB IDs
2BTP
5IQP
6BCR
6BD2
6BQT
6KZG
6KZH
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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