Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
TP53BP2 and OTUB2
Data Source:
BioGRID
(two hybrid)
TP53BP2
OTUB2
Description
tumor protein p53 binding protein 2
OTU deubiquitinase, ubiquitin aldehyde binding 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Cell Junction
Perinuclear Region Of Cytoplasm
Nucleus
Molecular Function
P53 Binding
Protein Binding
SH3 Domain Binding
Identical Protein Binding
NF-kappaB Binding
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
NEDD8-specific Protease Activity
Ubiquitin Binding
Biological Process
Cell Cycle
Signal Transduction
Regulation Of Apoptotic Process
Negative Regulation Of Cell Cycle
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Execution Phase Of Apoptosis
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Neuron Death
Regulation Of Signal Transduction By P53 Class Mediator
Protein Deubiquitination
Protein Phosphopantetheinylation
Protein K11-linked Deubiquitination
Protein K63-linked Deubiquitination
Protein K48-linked Deubiquitination
Negative Regulation Of Histone H2A K63-linked Ubiquitination
Negative Regulation Of Double-strand Break Repair
Pathways
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors
Ovarian tumor domain proteases
Drugs
Diseases
GWAS
Triptolide cytotoxicity (
26121980
)
Interacting Genes
122 interacting genes:
ADAMTS12
APP
APPL1
ARHGEF6
ATPAF2
ATXN7
AXIN1
BAG3
BAIAP2
BCAS2
BCL2
BCL2L1
CCDC13
CCDC57
CCDC85A
CCDC92
CDC5L
CEP55
CEP95
CGN
CRK
CSNK2B
CWF19L2
DCUN1D1
DDX6
DIRAS1
EEF1A1
EFHC1
ELOA
GCC1
GEM
GFAP
GOLGA1
GPS2
GRB2
H2BC4
H2BC9
HHEX
HIF1AN
HNRNPUL1
HSF2BP
INSYN2A
IQUB
KDM1A
KIF5A
LHX4
LMNB1
LMNB2
LMO4
MAGI1
MAPK8IP2
MOS
MRPL20
MTMR14
MTURN
NAE1
NDC80
NEDD4
NFKB1
NHSL2
NUTM1
OTUB2
PHF1
PIBF1
PLEKHF2
PLEKHN1
PLK1
POLR2L
PPHLN1
PPP1CA
PPP1CB
PPP1CC
PRAM1
PRKAB2
PRPF31
PTN
RALBP1
RASAL3
RASSF10
RASSF8
RELA
RGMA
RXRB
SCNM1
SETD5
SH3KBP1
SH3RF1
SHTN1
SIAH1
SIAH2
SUMO2
SUMO3
TANK
TBC1D22B
TCL1A
TP53
TRAF4
TROAP
TSGA10
TXLNA
TYK2
UBASH3A
UBASH3B
UBE3A
UBTD1
UNC119
USP4
UTP14A
WWP1
WWP2
YAP1
YES1
YOD1
YWHAG
YWHAQ
ZBTB4
ZFP91
ZGPAT
ZNF26
ZNF438
ZNF552
ZNF575
42 interacting genes:
APP
ARRDC3
CDIP1
CPSF6
DAZAP2
FAM168A
GLI2
KRT31
KRT40
LZTS2
MAGEA11
MID1
MID2
MKRN1
PHLDA2
PJA1
PLEKHB2
PMEPA1
RBCK1
REL
RFFL
RNF126
SIAH1
SPART
TP53BP2
TRAF6
TRIM2
TRIM25
TRIM26
TRIM27
TRIM39
TRIM5
TRIM54
TRIM55
TRIM63
TRIM8
TRIP6
U2AF2
UBC
UBE2N
USP21
USP28
Entrez ID
7159
78990
HPRD ID
11803
07620
Ensembl ID
ENSG00000143514
ENSG00000089723
Uniprot IDs
Q13625
Q96DC9
PDB IDs
1YCS
2UWQ
4A63
4IRV
6GHM
6HKP
1TFF
4FJV
5QIO
5QIP
5QIQ
5QIR
5QIS
5QIT
5QIU
5QIV
5QIW
5QIX
5QIY
5QIZ
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?