CENPC and TRIM14

Data Source:
BioGRID (two hybrid)

		CENPC	TRIM14
Description		centromere protein C	tripartite motif containing 14
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GO Annotations	Cellular Component	Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Chromosome, Centromeric Region Nucleoplasm Pericentric Heterochromatin Cytosol Nuclear Body Midbody	Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Cytosol Phagocytic Vesicle
	Molecular Function	DNA Binding Protein Binding Centromeric DNA Binding Identical Protein Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Mitotic Cell Cycle Chromosome Segregation CENP-A Containing Nucleosome Assembly Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly Monopolar Spindle Attachment To Meiosis I Kinetochore	Protein Polyubiquitination Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Protein Localization Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Interferon gamma signaling
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)	Multiple sclerosis ( 31604244)
Interacting Genes		7 interacting genes: DAXX ELOC MAPK14 MDC1 SUMO2 TRIM14 UBTF	84 interacting genes: ABCF3 ADAMTS12 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H BYSL CARD9 CCDC125 CCDC57 CCDC6 CENPC CIB3 CKS1B CSPP1 EIF3G ERCC3 ETFBKMT EXOC8 FAM50B FAT1 GOLGA2 GOLGA6L9 HERC3 HEXIM2 HNRNPF IHO1 ITM2A IVNS1ABP KAT2B KIF3A KIFC3 LAMTOR1 LNX1 MAPRE3 MITD1 MNAT1 MRPL24 MYO15B NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR1C POLR2G PPP2R3C PRDM6 PRKAB2 PRPF31 PTPN21 RAB5A RAB9A RAD51D RBM33 RLF RNF125 RNF20 SLF2 SMARCB1 SMIM3 SPG21 STK38 TAX1BP1 TMEM167A TRAF2 TSGA10 UBE2B UBE2N UNK VIM WDR35 WRNIP1 ZC4H2 ZFP36L2 ZGPAT ZNF652
Entrez ID		1060	9830
HPRD ID		00315	05948
Ensembl ID		ENSG00000145241	ENSG00000106785
Uniprot IDs		Q03188	A0A024R165 Q14142
PDB IDs		5LSJ 5LSK 6MUO 6MUP 6SE6 6SEE 6SEF	6JBM
Enriched GO Terms of Interacting Partners?
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