CENPC and UBTF

Data Source:
HPRD (in vivo, in vitro)

		CENPC	UBTF
Description		centromere protein C	upstream binding transcription factor
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GO Annotations	Cellular Component	Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Chromosome, Centromeric Region Nucleoplasm Pericentric Heterochromatin Cytosol Nuclear Body Midbody	Fibrillar Center Nucleus Nucleoplasm Nucleolus
	Molecular Function	DNA Binding Protein Binding Centromeric DNA Binding Identical Protein Binding	RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity Chromatin Binding RNA Binding Protein Binding Scaffold Protein Binding
	Biological Process	Mitotic Cell Cycle Chromosome Segregation CENP-A Containing Nucleosome Assembly Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly Monopolar Spindle Attachment To Meiosis I Kinetochore	RNA Polymerase I Preinitiation Complex Assembly Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Positive Regulation Of Transcription By RNA Polymerase I Regulation Of Glucose Mediated Signaling Pathway
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)	Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diverticular disease ( 30177863) Mean corpuscular hemoglobin concentration ( 29403010) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		7 interacting genes: DAXX ELOC MAPK14 MDC1 SUMO2 TRIM14 UBTF	33 interacting genes: AURKA CCNA2 CCND1 CCNE1 CDK2 CDK4 CENPC CHGB CREBBP CSNK2A1 EP300 IRS1 IRS2 LEF1 MAD1L1 MAPK1 MAPK3 MDM2 POLR1E POLR1G RB1 RBL2 RUNX2 SERPINH1 SMURF1 TAF1 TAF1A TAF1B TAF1C TAF1D TBP TCOF1 ZMYM2
Entrez ID		1060	7343
HPRD ID		00315	02814
Ensembl ID		ENSG00000145241	ENSG00000108312
Uniprot IDs		Q03188	P17480
PDB IDs		5LSJ 5LSK 6MUO 6MUP 6SE6 6SEE 6SEF	1K99 1L8Y 1L8Z 2HDZ
Enriched GO Terms of Interacting Partners?
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