GNAI3 and LPAR1

Number of citations of the paper that reports this interaction (PMID 9600933)
36

Data Source:
HPRD (in vitro)

		GNAI3	LPAR1
Gene Name		guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	lysophosphatidic acid receptor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Golgi Apparatus Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle Dendritic Spine Dendritic Shaft
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding	G-protein Alpha-subunit Binding G-protein Coupled Receptor Activity Protein Binding Phospholipid Binding PDZ Domain Binding Lysophosphatidic Acid Receptor Activity
	Biological Process	Transport Vesicle Fusion Cell Cycle Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Synaptic Transmission Blood Coagulation Platelet Activation Cell Division	Activation Of MAPK Activity G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Neuron Projection Development Bleb Assembly Positive Regulation Of Rho Protein Signal Transduction Myelination Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Dendritic Spine Development Cellular Response To Oxygen Levels Positive Regulation Of Smooth Muscle Cell Chemotaxis
Pathways		GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway Signaling by GPCR PLC beta mediated events Activation of GABAB receptors G alpha (s) signalling events Opioid Signalling Signal amplification G-protein mediated events Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Transmission across Chemical Synapses	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS		Major depressive disorder ( 20125088)	Corneal structure ( 23291589) Height ( 20881960)
Protein-Protein Interactions		40 interactors: AGTR2 ATP12A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 ESR1 GNB2 GNB4 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR	5 interactors: ARHGEF11 ARHGEF12 GNAI3 KRAS SLC9A3R2
Entrez ID		2773	1902
HPRD ID		00765	03790
Ensembl ID			ENSG00000198121
Uniprot IDs		P08754 Q5TZX1	Q5VZX0 Q92633
PDB IDs		2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Regulation Of Signaling G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Signal Transduction Regulation Of Signal Transduction Signaling Cell Communication Positive Regulation Of Metabolic Process Response To Stimulus Cellular Response To Stimulus Regulation Of Cellular Process Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Chemical Homeostasis Regulation Of Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Behavior Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Single-organism Behavior Metal Ion Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Homeostatic Process Cellular Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Dopamine Secretion Blood Circulation Regulation Of Phospholipase Activity Cellular Chemical Homeostasis Regulation Of Nitric-oxide Synthase Activity Cellular Response To Glucagon Stimulus Positive Regulation Of Cell Proliferation Regulation Of Hormone Secretion	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Axon Guidance Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Axonogenesis Axon Development Cellular Response To Growth Factor Stimulus Regulation Of Intracellular Signal Transduction Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Response To Growth Factor Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Small GTPase Mediated Signal Transduction Neuron Projection Morphogenesis Regulation Of Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Regulation Of Small GTPase Mediated Signal Transduction Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Catalytic Activity Enzyme Linked Receptor Protein Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Neuron Development Cell Morphogenesis Ras Protein Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Neuron Differentiation Positive Regulation Of Rho GTPase Activity Cell Projection Organization G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Regulation Of Rho GTPase Activity Locomotion Cell Surface Receptor Signaling Pathway Regulation Of Rho Protein Signal Transduction Apoptotic Signaling Pathway Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Catalytic Activity Regulation Of Cell Death Generation Of Neurons Blood Coagulation Neurogenesis Cell Division
Tagcloud ?		akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested	231t 4t1 debio dormancy edg2 h1 hairpinned hereafter histologic indicative inverse ki67 lpa1 lungs lysophosphatidic mb mda metastases metastasis nm23 nme1 nonmetastatic perk section shrna spontaneous tailed variance vehicle
Tagcloud (Difference) ?		akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested	231t 4t1 debio dormancy edg2 h1 hairpinned hereafter histologic indicative inverse ki67 lpa1 lungs lysophosphatidic mb mda metastases metastasis nm23 nme1 nonmetastatic perk section shrna spontaneous tailed variance vehicle
Tagcloud (Intersection) ?