GNAI3 and PTPRU

Number of citations of the paper that reports this interaction (PMID 16298104)
9

Data Source:
HPRD (in vivo, in vitro)

		GNAI3	PTPRU
Gene Name		guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	protein tyrosine phosphatase, receptor type, U
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Golgi Apparatus Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding
	Biological Process	Transport Vesicle Fusion Cell Cycle Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Synaptic Transmission Blood Coagulation Platelet Activation Cell Division	Protein Dephosphorylation Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Negative Regulation Of Cell Proliferation Single Organismal Cell-cell Adhesion Cell Differentiation Negative Regulation Of Cell Migration Organ Regeneration Homotypic Cell-cell Adhesion Protein Localization To Cell Surface Peptidyl-tyrosine Dephosphorylation Response To Glucocorticoid Canonical Wnt Signaling Pathway
Pathways		GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway Signaling by GPCR PLC beta mediated events Activation of GABAB receptors G alpha (s) signalling events Opioid Signalling Signal amplification G-protein mediated events Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Transmission across Chemical Synapses	Signaling by SCF-KIT
Drugs
Diseases
GWAS		Major depressive disorder ( 20125088)	Bipolar disorder and schizophrenia ( 20889312) Non-alcoholic fatty liver disease ( 23535911) Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		40 interactors: AGTR2 ATP12A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 ESR1 GNB2 GNB4 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR	8 interactors: CTNNB1 GNAI1 GNAI2 GNAI3 GNAO1 IRS1 KIT PPFIA3
Entrez ID		2773	10076
HPRD ID		00765	03908
Ensembl ID			ENSG00000060656
Uniprot IDs		P08754 Q5TZX1	Q92729
PDB IDs		2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Regulation Of Signaling G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Signal Transduction Regulation Of Signal Transduction Signaling Cell Communication Positive Regulation Of Metabolic Process Response To Stimulus Cellular Response To Stimulus Regulation Of Cellular Process Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Chemical Homeostasis Regulation Of Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Behavior Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Single-organism Behavior Metal Ion Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Homeostatic Process Cellular Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Dopamine Secretion Blood Circulation Regulation Of Phospholipase Activity Cellular Chemical Homeostasis Regulation Of Nitric-oxide Synthase Activity Cellular Response To Glucagon Stimulus Positive Regulation Of Cell Proliferation Regulation Of Hormone Secretion	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Synaptic Transmission Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cell Activation Cell-cell Signaling Cell Surface Receptor Signaling Pathway Cell Division Response To Stress Signaling Cell Communication Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Regulation Of Calcium Ion Transport Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of CAMP Biosynthetic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of CAMP Metabolic Process Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Nucleotide Metabolic Process Positive Regulation Of Cell Proliferation Response To Organonitrogen Compound Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Phosphorylation Regulation Of Synaptic Transmission Regulation Of Phosphatidylinositol 3-kinase Activity Vesicle Fusion Response To Hormone Regulation Of Adenylate Cyclase Activity Regulation Of Neuronal Synaptic Plasticity Signal Transduction Regulation Of Lipid Kinase Activity Regulation Of Cyclase Activity Positive Regulation Of Stem Cell Proliferation Organelle Fusion Blood Coagulation Hemostasis G-protein Coupled Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Mast Cell Proliferation Response To Peptide Hormone Regulation Of CAMP Biosynthetic Process Response To Peptide Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction
Tagcloud ?		akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested	adhesion adjacent attenuation catenin colon delivered dephosphorylating find focal fragment full gastric isoform kda knockdown lentivirus localized lowly lysine phosphatase reducing relatively respective serve shrna suppressor tissues tyrosine
Tagcloud (Difference) ?		akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested	adhesion adjacent attenuation catenin colon delivered dephosphorylating find focal fragment full gastric isoform kda knockdown lentivirus localized lowly lysine phosphatase reducing relatively respective serve shrna suppressor tissues tyrosine
Tagcloud (Intersection) ?