GNAI3 and CCDC88C

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		GNAI3	CCDC88C
Gene Name		guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	coiled-coil domain containing 88C
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Golgi Apparatus Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Vesicular Exosome	Cytoplasm
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding	PDZ Domain Binding Protein Self-association
	Biological Process	Transport Vesicle Fusion Cell Cycle Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Synaptic Transmission Blood Coagulation Platelet Activation Cell Division	Regulation Of Protein Phosphorylation Wnt Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Protein Destabilization Protein Homooligomerization
Pathways		GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway Signaling by GPCR PLC beta mediated events Activation of GABAB receptors G alpha (s) signalling events Opioid Signalling Signal amplification G-protein mediated events Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Transmission across Chemical Synapses	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt negative regulation of TCF-dependent signaling by DVL-interacting proteins Signaling by WNT in cancer
Drugs
Diseases
GWAS		Major depressive disorder ( 20125088)	Breast cancer ( 23535729)
Protein-Protein Interactions		40 interactors: AGTR2 ATP12A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 ESR1 GNB2 GNB4 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR	5 interactors: APP DVL1 GNAI3 ITSN2 MAPK8
Entrez ID		2773	440193
HPRD ID		00765	19136
Ensembl ID			ENSG00000015133
Uniprot IDs		P08754 Q5TZX1	B4DZB8 Q9P219
PDB IDs		2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Regulation Of Signaling G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Signal Transduction Regulation Of Signal Transduction Signaling Cell Communication Positive Regulation Of Metabolic Process Response To Stimulus Cellular Response To Stimulus Regulation Of Cellular Process Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Chemical Homeostasis Regulation Of Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Behavior Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Single-organism Behavior Metal Ion Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Homeostatic Process Cellular Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Dopamine Secretion Blood Circulation Regulation Of Phospholipase Activity Cellular Chemical Homeostasis Regulation Of Nitric-oxide Synthase Activity Cellular Response To Glucagon Stimulus Positive Regulation Of Cell Proliferation Regulation Of Hormone Secretion	Collateral Sprouting Regulation Of Protein Binding Regulation Of Catalytic Activity Regulation Of Binding Neuromuscular Junction Development Negative Regulation Of Protein Binding Developmental Cell Growth Negative Regulation Of Binding Neuromuscular Process Negative Regulation Of Catalytic Activity Dendrite Development Developmental Growth Involved In Morphogenesis Cell Growth Synaptic Growth At Neuromuscular Junction Synapse Organization Convergent Extension Involved In Neural Plate Elongation Collateral Sprouting In Absence Of Injury Platelet Activation Positive Regulation Of Hydrolase Activity Regulation Of Signal Transduction Axon Midline Choice Point Recognition JUN Phosphorylation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Deacetylase Activity Convergent Extension Involved In Organogenesis Regulation Of Signaling Axon Choice Point Recognition Developmental Growth Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Proteolysis Positive Regulation Of Determination Of Dorsal Identity Protein Localization To Microtubule Neural Plate Morphogenesis Neuron Remodeling Positive Regulation Of Metabolic Process Response To Light Stimulus Vesicle-mediated Transport Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Axon Guidance Cellular Response To Nitric Oxide Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Response To Oxidative Stress Blood Coagulation Hemostasis Convergent Extension
Tagcloud ?		akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested	ataxia ataxias atrophy autosomal causative cerebellar cerebellum characterised coil coiled congenital cure dominant exhibits exome expands g1391a genetically jnk missense neurological pontocerebellar r464h sca scas spinocerebellar triggers unveils
Tagcloud (Difference) ?		akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested	ataxia ataxias atrophy autosomal causative cerebellar cerebellum characterised coil coiled congenital cure dominant exhibits exome g1391a genetically jnk missense neurological pontocerebellar r464h sca scas spinocerebellar triggers unveils
Tagcloud (Intersection) ?		expands