GNAI3 and HTR1A

Number of citations of the paper that reports this interaction (PMID 8218170)
14

Data Source:
HPRD (in vivo, in vitro)

		GNAI3	HTR1A
Gene Name		guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Golgi Apparatus Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding	Serotonin Receptor Activity Protein Binding
	Biological Process	Transport Vesicle Fusion Cell Cycle Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Synaptic Transmission Blood Coagulation Platelet Activation Cell Division	Behavioral Fear Response G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Serotonin Secretion Exploration Behavior Regulation Of Dopamine Metabolic Process Vasoconstriction Serotonin Metabolic Process Regulation Of Hormone Secretion Regulation Of Behavior
Pathways		GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway Signaling by GPCR PLC beta mediated events Activation of GABAB receptors G alpha (s) signalling events Opioid Signalling Signal amplification G-protein mediated events Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Transmission across Chemical Synapses	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors
Drugs			Eletriptan Ziprasidone Methysergide Cabergoline Ropinirole Zolmitriptan Amitriptyline Olanzapine Clozapine Pramipexole Chlorpromazine Buspirone Nortriptyline Propranolol Lisuride Trazodone Sumatriptan Apomorphine Trimipramine Risperidone Alprenolol Ondansetron Naratriptan Pindolol Ergoloid mesylate Doxepin Nefazodone Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Penbutolol Yohimbine Acepromazine Alverine Molindone Pipotiazine Thioproperazine Iloperidone Rotigotine Asenapine Vilazodone Bopindolol Cinitapride Lurasidone
Diseases
GWAS		Major depressive disorder ( 20125088)	Alcohol and nictotine co-dependence ( 23216389) Body mass index ( 20935630)
Protein-Protein Interactions		40 interactors: AGTR2 ATP12A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 ESR1 GNB2 GNB4 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR	7 interactors: GABBR2 GNAI3 GPR26 HTR1B HTR1D S1PR1 S1PR3
Entrez ID		2773	3350
HPRD ID		00765	00190
Ensembl ID
Uniprot IDs		P08754 Q5TZX1	A8K5W4 P08908 Q5ZGX3
PDB IDs		2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Regulation Of Signaling G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Signal Transduction Regulation Of Signal Transduction Signaling Cell Communication Positive Regulation Of Metabolic Process Response To Stimulus Cellular Response To Stimulus Regulation Of Cellular Process Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Chemical Homeostasis Regulation Of Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Behavior Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Single-organism Behavior Metal Ion Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Homeostatic Process Cellular Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Dopamine Secretion Blood Circulation Regulation Of Phospholipase Activity Cellular Chemical Homeostasis Regulation Of Nitric-oxide Synthase Activity Cellular Response To Glucagon Stimulus Positive Regulation Of Cell Proliferation Regulation Of Hormone Secretion	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Sphingosine-1-phosphate Signaling Pathway Serotonin Receptor Signaling Pathway Synaptic Transmission Negative Regulation Of Adenylate Cyclase Activity Regulation Of Behavior Negative Regulation Of Lyase Activity Signal Transduction Vasoconstriction Signaling Cell Communication Cell-cell Signaling Regulation Of Adenylate Cyclase Activity Cellular Response To Stimulus Regulation Of Cyclase Activity Regulation Of Blood Vessel Size Regulation Of Tube Size Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Negative Regulation Of Establishment Of Endothelial Barrier Cellular Response To Temperature Stimulus Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Response To Stimulus Growth Involved In Heart Morphogenesis Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Serotonin Secretion Intestine Smooth Muscle Contraction Cytosolic Calcium Ion Homeostasis Negative Regulation Of Endothelial Cell Differentiation Regulation Of Serotonin Secretion Drinking Behavior Negative Regulation Of Synaptic Transmission, GABAergic Cellular Calcium Ion Homeostasis Negative Regulation Of Stress Fiber Assembly Calcium Ion Homeostasis Blood Circulation G-protein Coupled Receptor Internalization Negative Regulation Of Actin Filament Bundle Assembly Blood Vessel Maturation Negative Regulation Of Synaptic Transmission, Glutamatergic Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway
Tagcloud ?		akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested	analysing asynchronous chrna5 chrna7 circuit clamp develops earliest ergic grik1 grin2a htr1b innervation kcc2 lmc locomotor medial muscarinic neuromuscular neurotransmitter nicotinic ordered organised patch patterned recordings subtly synchronous transmitter
Tagcloud (Difference) ?		akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested	analysing asynchronous chrna5 chrna7 circuit clamp develops earliest ergic grik1 grin2a htr1b innervation kcc2 lmc locomotor medial muscarinic neuromuscular neurotransmitter nicotinic ordered organised patch patterned recordings subtly synchronous transmitter
Tagcloud (Intersection) ?