GNAI3 and RGS7

Number of citations of the paper that reports this interaction (PMID 10092682)
12

Data Source:
HPRD (in vitro)

		GNAI3	RGS7
Gene Name		guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	regulator of G-protein signaling 7
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Golgi Apparatus Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Dendrite Terminus
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding	Signal Transducer Activity GTPase Activator Activity G-protein Beta-subunit Binding
	Biological Process	Transport Vesicle Fusion Cell Cycle Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Synaptic Transmission Blood Coagulation Platelet Activation Cell Division	G-protein Coupled Receptor Signaling Pathway Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway Signaling by GPCR PLC beta mediated events Activation of GABAB receptors G alpha (s) signalling events Opioid Signalling Signal amplification G-protein mediated events Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Transmission across Chemical Synapses	Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events
Drugs
Diseases
GWAS		Major depressive disorder ( 20125088)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		40 interactors: AGTR2 ATP12A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 ESR1 GNB2 GNB4 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR	12 interactors: GNAI1 GNAI3 GNAO1 GNAQ GNAZ GNB5 MSX1 PKD1 PRKCA SNAPIN YWHAB YWHAQ
Entrez ID		2773	6000
HPRD ID		00765	03948
Ensembl ID			ENSG00000182901
Uniprot IDs		P08754 Q5TZX1	P49802
PDB IDs		2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S	2A72 2D9J
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Regulation Of Signaling G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Signal Transduction Regulation Of Signal Transduction Signaling Cell Communication Positive Regulation Of Metabolic Process Response To Stimulus Cellular Response To Stimulus Regulation Of Cellular Process Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Chemical Homeostasis Regulation Of Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Behavior Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Single-organism Behavior Metal Ion Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Homeostatic Process Cellular Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Dopamine Secretion Blood Circulation Regulation Of Phospholipase Activity Cellular Chemical Homeostasis Regulation Of Nitric-oxide Synthase Activity Cellular Response To Glucagon Stimulus Positive Regulation Of Cell Proliferation Regulation Of Hormone Secretion	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Signaling Cell Communication Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Signal Transduction Negative Regulation Of Transport Regulation Of Intracellular Transport Membrane Organization Platelet Activation Vesicle Fusion Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Cellular Localization Organelle Fusion Cellular Response To Stimulus Regulation Of Establishment Of Protein Localization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization Membrane Fusion Positive Regulation Of Organelle Organization Nervous System Development Positive Regulation Of Blood Vessel Endothelial Cell Migration Blood Coagulation Hemostasis Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Lyase Activity Response To Stimulus Cytoplasmic Sequestering Of Protein Central Nervous System Development Regulation Of Rhodopsin Mediated Signaling Pathway Detection Of Abiotic Stimulus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Intrinsic Apoptotic Signaling Pathway Rhodopsin Mediated Signaling Pathway Negative Regulation Of CAMP Metabolic Process Cartilage Development Positive Regulation Of Apoptotic Signaling Pathway Skeletal System Development Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Dopamine Receptor Signaling Pathway Vesicle Organization Regulation Of Body Fluid Levels Synaptic Transmission Wound Healing Negative Regulation Of Nucleotide Metabolic Process Negative Regulation Of Calcium Ion Transport Regulation Of Protein Transport
Tagcloud ?		akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested	2a ag490 attenuated cortex corticosterone dependently desensitization frontal hormone hypothalamic increases jak mediating necessary nucleus olanzapine oxytocin paraventricular phospholipase prevented rat reductions regulator release reverse serotonin stat stimulated understand
Tagcloud (Difference) ?		akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested	2a ag490 attenuated cortex corticosterone dependently desensitization frontal hormone hypothalamic increases jak mediating necessary nucleus olanzapine oxytocin paraventricular phospholipase prevented rat reductions regulator release reverse serotonin stat stimulated understand
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