LPAR1

Gene Name		lysophosphatidic acid receptor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle Dendritic Spine Dendritic Shaft
	Molecular Function	G-protein Alpha-subunit Binding G-protein Coupled Receptor Activity Protein Binding Phospholipid Binding PDZ Domain Binding Lysophosphatidic Acid Receptor Activity
	Biological Process	Activation Of MAPK Activity G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Neuron Projection Development Bleb Assembly Positive Regulation Of Rho Protein Signal Transduction Myelination Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Dendritic Spine Development Cellular Response To Oxygen Levels Positive Regulation Of Smooth Muscle Cell Chemotaxis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS		Corneal structure ( 23291589) Height ( 20881960)
Protein-protein Interactions		5 interactors: ARHGEF11 ARHGEF12 GNAI3 KRAS SLC9A3R2
Entrez ID		1902
HPRD ID		03790
Ensembl ID		ENSG00000198121
Uniprot IDs		Q5VZX0 Q92633
PDB IDs
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Axon Guidance Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Axonogenesis Axon Development Cellular Response To Growth Factor Stimulus Regulation Of Intracellular Signal Transduction Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Response To Growth Factor Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Small GTPase Mediated Signal Transduction Neuron Projection Morphogenesis Regulation Of Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Regulation Of Small GTPase Mediated Signal Transduction Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Catalytic Activity Enzyme Linked Receptor Protein Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Neuron Development Cell Morphogenesis Ras Protein Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Neuron Differentiation Positive Regulation Of Rho GTPase Activity Cell Projection Organization G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Regulation Of Rho GTPase Activity Locomotion Cell Surface Receptor Signaling Pathway Regulation Of Rho Protein Signal Transduction Apoptotic Signaling Pathway Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Catalytic Activity Regulation Of Cell Death Generation Of Neurons Blood Coagulation Neurogenesis Cell Division
Tagcloud ?		231t 4t1 debio dormancy edg2 h1 hairpinned hereafter histologic indicative inverse ki67 lpa1 lungs lysophosphatidic mb mda metastases metastasis nm23 nme1 nonmetastatic perk section shrna spontaneous tailed variance vehicle