GNAI3 and RGS16

Number of citations of the paper that reports this interaction (PMID 9079700)
22

Data Source:
HPRD (in vitro)

		GNAI3	RGS16
Gene Name		guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	regulator of G-protein signaling 16
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Golgi Apparatus Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding	GTPase Activator Activity Protein Binding Calmodulin Binding
	Biological Process	Transport Vesicle Fusion Cell Cycle Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Synaptic Transmission Blood Coagulation Platelet Activation Cell Division	Visual Perception Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway Signaling by GPCR PLC beta mediated events Activation of GABAB receptors G alpha (s) signalling events Opioid Signalling Signal amplification G-protein mediated events Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Major depressive disorder ( 20125088)
Protein-Protein Interactions		40 interactors: AGTR2 ATP12A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 ESR1 GNB2 GNB4 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR	14 interactors: CREB3L2 CSK EGFR GDE1 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAT1 LYN SRC ST14
Entrez ID		2773	6004
HPRD ID		00765	03945
Ensembl ID			ENSG00000143333
Uniprot IDs		P08754 Q5TZX1	O15492
PDB IDs		2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S	2BT2 2IK8
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Regulation Of Signaling G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Signal Transduction Regulation Of Signal Transduction Signaling Cell Communication Positive Regulation Of Metabolic Process Response To Stimulus Cellular Response To Stimulus Regulation Of Cellular Process Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Chemical Homeostasis Regulation Of Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Behavior Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Single-organism Behavior Metal Ion Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Homeostatic Process Cellular Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Dopamine Secretion Blood Circulation Regulation Of Phospholipase Activity Cellular Chemical Homeostasis Regulation Of Nitric-oxide Synthase Activity Cellular Response To Glucagon Stimulus Positive Regulation Of Cell Proliferation Regulation Of Hormone Secretion	Platelet Activation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Positive Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Response To Stress Signal Transduction Peptidyl-tyrosine Autophosphorylation G-protein Coupled Receptor Signaling Pathway Signaling Regulation Of Protein Kinase Activity Cell Differentiation Positive Regulation Of Metabolic Process Cell Communication Regulation Of Kinase Activity Regulation Of Intracellular Transport Regulation Of ERK1 And ERK2 Cascade Response To Organonitrogen Compound Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Protein Autophosphorylation Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Organ Development Neuron Development Central Nervous System Development Cellular Response To Stimulus Positive Regulation Of Phospholipase Activity T Cell Costimulation Positive Regulation Of Transferase Activity System Development Regulation Of Phospholipase Activity Regulation Of Protein Phosphorylation Neurogenesis Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lipase Activity Regulation Of MAPK Cascade Regulation Of MAP Kinase Activity Regulation Of Protein Transport Tissue Development Neuron Differentiation Regulation Of Establishment Of Protein Localization
Tagcloud ?		akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested	aspc bxpc candidates coexpressing cooperate cross discovery downregulated exogenously inactivated inhibit inhibiting invasion metastases migration oncogenic p53 panc pancreatic prb profiling rb1 reoccurrence suppressors talk toward tumorigenesis viability wi38
Tagcloud (Difference) ?		akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested	aspc bxpc candidates coexpressing cooperate cross discovery downregulated exogenously inactivated inhibit inhibiting invasion metastases migration oncogenic p53 panc pancreatic prb profiling rb1 reoccurrence suppressors talk toward tumorigenesis viability wi38
Tagcloud (Intersection) ?