GNAI3 and NUCB2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GNAI3	NUCB2
Gene Name		guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	nucleobindin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Golgi Apparatus Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Vesicular Exosome	Extracellular Space Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding	DNA Binding Calcium Ion Binding Protein Binding
	Biological Process	Transport Vesicle Fusion Cell Cycle Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Synaptic Transmission Blood Coagulation Platelet Activation Cell Division
Pathways		GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway Signaling by GPCR PLC beta mediated events Activation of GABAB receptors G alpha (s) signalling events Opioid Signalling Signal amplification G-protein mediated events Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Major depressive disorder ( 20125088)	Height ( 20881960)
Protein-Protein Interactions		40 interactors: AGTR2 ATP12A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 ESR1 GNB2 GNB4 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR	8 interactors: GADD45A GNAI3 GNAS NDN NR1I2 SMARCD1 STAR XPO1
Entrez ID		2773	4925
HPRD ID		00765	09726
Ensembl ID			ENSG00000070081
Uniprot IDs		P08754 Q5TZX1	E9PKG6 P80303
PDB IDs		2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Regulation Of Signaling G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Signal Transduction Regulation Of Signal Transduction Signaling Cell Communication Positive Regulation Of Metabolic Process Response To Stimulus Cellular Response To Stimulus Regulation Of Cellular Process Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Chemical Homeostasis Regulation Of Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Behavior Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Single-organism Behavior Metal Ion Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Homeostatic Process Cellular Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Dopamine Secretion Blood Circulation Regulation Of Phospholipase Activity Cellular Chemical Homeostasis Regulation Of Nitric-oxide Synthase Activity Cellular Response To Glucagon Stimulus Positive Regulation Of Cell Proliferation Regulation Of Hormone Secretion	Response To Drug Cellular Response To Catecholamine Stimulus Genetic Imprinting Cyclic Purine Nucleotide Metabolic Process Regulation Of Metabolic Process Cyclic Nucleotide Biosynthetic Process Cellular Response To Organic Substance Regulation Of Adenylate Cyclase Activity Signal Transduction Regulation Of Cyclase Activity Cellular Response To Organic Cyclic Compound Signaling Cyclic Nucleotide Metabolic Process Cellular Response To Lipid Cell Communication Drug Export Post-embryonic Body Morphogenesis Cellular Response To Luteinizing Hormone Stimulus Circadian Sleep/wake Cycle, REM Sleep Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Response To Organic Substance Response To Luteinizing Hormone Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Cellular Response To Stimulus Response To Growth Factor Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Post-embryonic Development Ribosomal Small Subunit Export From Nucleus Insecticide Metabolic Process Response To Ionizing Radiation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Xenobiotic Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Purine Nucleotide Biosynthetic Process Regulation Of Gene Expression Ribose Phosphate Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Steroid Hormone Stimulus Cell Surface Receptor Signaling Pathway Circadian Sleep/wake Cycle Process Fractalkine Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Platelet Activation Xenobiotic Transport Regulation Of Gene Expression, Epigenetic
Tagcloud ?		akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested	animal birth blot catch diets difference divided feeding gastric ghrelin groups growth immediately interact intrauterine iugr mucosa nesfatin newborn nutritional observation pregnancy produce rats retardation significance starting weaning whole
Tagcloud (Difference) ?		akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested	animal birth blot catch diets difference divided feeding gastric ghrelin groups growth immediately interact intrauterine iugr mucosa nesfatin newborn nutritional observation pregnancy produce rats retardation significance starting weaning whole
Tagcloud (Intersection) ?