GNAI3 and CCR5

Number of citations of the paper that reports this interaction (PMID 15251452)
5

Data Source:
HPRD (in vivo)

		GNAI3	CCR5
Gene Name		guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	chemokine (C-C motif) receptor 5 (gene/pseudogene)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Golgi Apparatus Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Vesicular Exosome	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding	Actin Binding Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	Transport Vesicle Fusion Cell Cycle Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Synaptic Transmission Blood Coagulation Platelet Activation Cell Division	MAPK Cascade Dendritic Cell Chemotaxis Calcium Ion Transport Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Viral Process Calcium-mediated Signaling Signaling Entry Into Host Cell Chemokine-mediated Signaling Pathway Response To Cholesterol Cellular Response To Lipopolysaccharide
Pathways		GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway Signaling by GPCR PLC beta mediated events Activation of GABAB receptors G alpha (s) signalling events Opioid Signalling Signal amplification G-protein mediated events Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Transmission across Chemical Synapses	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR HIV Infection Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Early Phase of HIV Life Cycle GPCR downstream signaling HIV Life Cycle Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events Binding and entry of HIV virion
Drugs			Maraviroc
Diseases
GWAS		Major depressive disorder ( 20125088)	Celiac disease ( 20190752)
Protein-Protein Interactions		40 interactors: AGTR2 ATP12A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 ESR1 GNB2 GNB4 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR	41 interactors: ADRBK1 ADRBK2 AFP ARL6IP5 ARRB1 CCL11 CCL13 CCL14 CCL16 CCL2 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCL8 CD4 CST9L CTBP2 CXCR4 DNM2 ETV5 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ IL24 JAK1 JAK2 LCK ORM1 PRAF2 PSMA5 PTK2 PTK2B STAT1 STAT3 STAT5A TXK
Entrez ID		2773	1234
HPRD ID		00765	03223
Ensembl ID			ENSG00000160791
Uniprot IDs		P08754 Q5TZX1	A0A502 P51681 Q38L21
PDB IDs		2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S	1ND8 1NE0 1OPN 1OPT 1OPW 2L87 2RLL 2RRS 4MBS
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Regulation Of Signaling G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Signal Transduction Regulation Of Signal Transduction Signaling Cell Communication Positive Regulation Of Metabolic Process Response To Stimulus Cellular Response To Stimulus Regulation Of Cellular Process Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Chemical Homeostasis Regulation Of Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Behavior Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Single-organism Behavior Metal Ion Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Homeostatic Process Cellular Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Dopamine Secretion Blood Circulation Regulation Of Phospholipase Activity Cellular Chemical Homeostasis Regulation Of Nitric-oxide Synthase Activity Cellular Response To Glucagon Stimulus Positive Regulation Of Cell Proliferation Regulation Of Hormone Secretion	Response To Stress Cell Chemotaxis Defense Response Immune Response Immune System Process Cellular Response To Stimulus Inflammatory Response Cell Migration Cell Motility Response To Stimulus Response To External Stimulus Signaling Locomotion Cell Communication Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Signal Transduction Regulation Of Cell Proliferation Chemotaxis Movement Of Cell Or Subcellular Component Positive Regulation Of Metabolic Process Eosinophil Chemotaxis Eosinophil Migration Cellular Metal Ion Homeostasis Cell Activation Cellular Cation Homeostasis Positive Regulation Of Signal Transduction Regulation Of Lymphocyte Migration Cellular Ion Homeostasis Metal Ion Homeostasis Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Natural Killer Cell Chemotaxis Cellular Chemical Homeostasis Regulation Of Signal Transduction Regulation Of Signaling Chemical Homeostasis Response To Cytokine Ion Homeostasis Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Leukocyte Chemotaxis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Granulocyte Chemotaxis Cellular Response To Growth Hormone Stimulus
Tagcloud ?		akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested	7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Difference) ?		akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested	7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Intersection) ?