GNAI3 and RGS18

Number of citations of the paper that reports this interaction (PMID 11955952)
14

Data Source:
HPRD (in vitro)

		GNAI3	RGS18
Gene Name		guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	regulator of G-protein signaling 18
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Golgi Apparatus Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane
	Molecular Function	GTPase Activity Signal Transducer Activity GTP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding	GTPase Activator Activity
	Biological Process	Transport Vesicle Fusion Cell Cycle Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Synaptic Transmission Blood Coagulation Platelet Activation Cell Division	G-protein Coupled Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway Signaling by GPCR PLC beta mediated events Activation of GABAB receptors G alpha (s) signalling events Opioid Signalling Signal amplification G-protein mediated events Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Transmission across Chemical Synapses	G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK G alpha (i) signalling events
Drugs
Diseases
GWAS		Major depressive disorder ( 20125088)
Protein-Protein Interactions		40 interactors: AGTR2 ATP12A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 ESR1 GNB2 GNB4 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR	5 interactors: APP GNAI1 GNAI2 GNAI3 GNAQ
Entrez ID		2773	64407
HPRD ID		00765	06224
Ensembl ID			ENSG00000150681
Uniprot IDs		P08754 Q5TZX1	Q9NS28
PDB IDs		2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S	2DLV 2JM5 2OWI
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Hydrolase Activity Positive Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Regulation Of Signaling G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Signal Transduction Regulation Of Signal Transduction Signaling Cell Communication Positive Regulation Of Metabolic Process Response To Stimulus Cellular Response To Stimulus Regulation Of Cellular Process Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Chemical Homeostasis Regulation Of Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Behavior Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Single-organism Behavior Metal Ion Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Homeostatic Process Cellular Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Dopamine Secretion Blood Circulation Regulation Of Phospholipase Activity Cellular Chemical Homeostasis Regulation Of Nitric-oxide Synthase Activity Cellular Response To Glucagon Stimulus Positive Regulation Of Cell Proliferation Regulation Of Hormone Secretion	Platelet Activation Blood Coagulation Hemostasis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Neuron Remodeling Negative Regulation Of Catalytic Activity Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Negative Regulation Of CAMP Biosynthetic Process Neuron Maturation Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Vesicle Fusion Regulation Of Adenylate Cyclase Activity Cell Division Glutamate Receptor Signaling Pathway Response To Stress Regulation Of Phosphorus Metabolic Process Regulation Of Cyclase Activity Organelle Fusion Regulation Of CAMP Biosynthetic Process Synaptic Transmission Regulation Of CAMP Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Membrane Fusion Regulation Of Kinase Activity Cell Maturation Synaptic Growth At Neuromuscular Junction Regulation Of Catalytic Activity Cell-cell Signaling Signal Transduction Collateral Sprouting In Absence Of Injury Vesicle Organization Signaling Regulation Of Protein Phosphorylation Cell Communication Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Regulation Of Phosphorylation
Tagcloud ?		akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested	3gamma a2 activates adp amp block cyclic detachment gmp gq gtpase heterotrimeric nitric pka pkgi platelet platelets pronounced prostacyclin q serine serines stimulates stores talk thrombin thromboxane trigger turns
Tagcloud (Difference) ?		akin angles asymmetric combine cooperatively delamination divisions e15 embryogenesis epidermis expands galphai3 genetics hitherto lend lentiviral lgn minsc morphogenesis orientation par3 perpendicular planar polarize revealing spindle uncover unspecified untested	3gamma a2 activates adp amp block cyclic detachment gmp gq gtpase heterotrimeric nitric pka pkgi platelet platelets pronounced prostacyclin q serine serines stimulates stores talk thrombin thromboxane trigger turns
Tagcloud (Intersection) ?