LPAR1 and ARHGEF11

Number of citations of the paper that reports this interaction (PMID 15755723)
36

Data Source:
HPRD (in vivo, in vitro)

		LPAR1	ARHGEF11
Gene Name		lysophosphatidic acid receptor 1	Rho guanine nucleotide exchange factor (GEF) 11
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle Dendritic Spine Dendritic Shaft	Intracellular Cytoplasm Cytosol Membrane
	Molecular Function	G-protein Alpha-subunit Binding G-protein Coupled Receptor Activity Protein Binding Phospholipid Binding PDZ Domain Binding Lysophosphatidic Acid Receptor Activity	G-protein Coupled Receptor Binding Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Activation Of MAPK Activity G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Neuron Projection Development Bleb Assembly Positive Regulation Of Rho Protein Signal Transduction Myelination Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Dendritic Spine Development Cellular Response To Oxygen Levels Positive Regulation Of Smooth Muscle Cell Chemotaxis	Cytokinesis Regulation Of Cell Growth Movement Of Cell Or Subcellular Component Striated Muscle Contraction G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of Rho GTPase Activity Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Lysosphingolipid and LPA receptors	Signaling by GPCR Signalling by NGF Axon guidance Semaphorin interactions Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		Corneal structure ( 23291589) Height ( 20881960)
Protein-Protein Interactions		5 interactors: ARHGEF11 ARHGEF12 GNAI3 KRAS SLC9A3R2	13 interactors: ABCA1 CDC42 GNA12 GNA13 LPAR1 LPAR2 MAP1A MAP1B PLXNB1 PLXNB2 PLXNB3 RHOA SLC1A6
Entrez ID		1902	9826
HPRD ID		03790	09302
Ensembl ID		ENSG00000198121	ENSG00000132694
Uniprot IDs		Q5VZX0 Q92633	F8W8P9 O15085
PDB IDs			1HTJ 1XCG 2DLS 3KZ1 3T06
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Axon Guidance Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Axonogenesis Axon Development Cellular Response To Growth Factor Stimulus Regulation Of Intracellular Signal Transduction Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Response To Growth Factor Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Small GTPase Mediated Signal Transduction Neuron Projection Morphogenesis Regulation Of Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Regulation Of Small GTPase Mediated Signal Transduction Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Catalytic Activity Enzyme Linked Receptor Protein Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Neuron Development Cell Morphogenesis Ras Protein Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Neuron Differentiation Positive Regulation Of Rho GTPase Activity Cell Projection Organization G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Regulation Of Rho GTPase Activity Locomotion Cell Surface Receptor Signaling Pathway Regulation Of Rho Protein Signal Transduction Apoptotic Signaling Pathway Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Catalytic Activity Regulation Of Cell Death Generation Of Neurons Blood Coagulation Neurogenesis Cell Division	Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Positive Regulation Of Cell Projection Organization Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Axonogenesis Positive Regulation Of Neuron Projection Development Regulation Of Cellular Component Organization Positive Regulation Of Cell Development Cell Surface Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Neuron Differentiation Regulation Of Rho Protein Signal Transduction Regulation Of Locomotion Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Movement Regulation Of Neuron Projection Development Regulation Of Axonogenesis Regulation Of Cell Shape Semaphorin-plexin Signaling Pathway Positive Regulation Of Neurogenesis Regulation Of Cell Development Positive Regulation Of Cell Differentiation Apolipoprotein A-I-mediated Signaling Pathway Rho Protein Signal Transduction Axonogenesis Generation Of Neurons Signaling Regulation Of Cell Differentiation Regulation Of Neuron Differentiation Cell Communication Axon Development Positive Regulation Of Phospholipase Activity Anatomical Structure Morphogenesis Neurogenesis Cell Morphogenesis Involved In Neuron Differentiation Cell Differentiation Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Neuron Projection Morphogenesis Cell Projection Organization Regulation Of Ras Protein Signal Transduction Regulation Of Neurogenesis Regulation Of Signal Transduction Cell Morphogenesis Involved In Differentiation Ossification Involved In Bone Maturation Signal Transduction Positive Regulation Of Intracellular Signal Transduction Bone Maturation
Tagcloud ?		231t 4t1 debio dormancy edg2 h1 hairpinned hereafter histologic indicative inverse ki67 lpa1 lungs lysophosphatidic mb mda metastases metastasis nm23 nme1 nonmetastatic perk section shrna spontaneous tailed variance vehicle
Tagcloud (Difference) ?		231t 4t1 debio dormancy edg2 h1 hairpinned hereafter histologic indicative inverse ki67 lpa1 lungs lysophosphatidic mb mda metastases metastasis nm23 nme1 nonmetastatic perk section shrna spontaneous tailed variance vehicle
Tagcloud (Intersection) ?