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TIAM1 and BTRC
Data Source:
BioGRID
(pull down)
TIAM1
BTRC
Description
TIAM Rac1 associated GEF 1
beta-transducin repeat containing E3 ubiquitin protein ligase
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
Microtubule
Plasma Membrane
Cell-cell Junction
Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Ruffle Membrane
Neuronal Cell Body
Dendritic Spine
Cell-cell Contact Zone
Axonal Growth Cone
Main Axon
Synapse
Glutamatergic Synapse
Extrinsic Component Of Postsynaptic Density Membrane
Nucleoplasm
Cytosol
SCF Ubiquitin Ligase Complex
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Microtubule Binding
Lipid Binding
Kinase Binding
Receptor Tyrosine Kinase Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Beta-catenin Binding
Ligase Activity
Protein Phosphorylated Amino Acid Binding
Protein Dimerization Activity
Ubiquitin Protein Ligase Activity
Ubiquitin Ligase-substrate Adaptor Activity
Ubiquitin Ligase Activator Activity
Biological Process
Cardiac Muscle Hypertrophy
Apoptotic Process
Cell-matrix Adhesion
G Protein-coupled Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Positive Regulation Of Cell Population Proliferation
Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Epithelial To Mesenchymal Transition
Cell Migration
Rac Protein Signal Transduction
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Binding
Cellular Protein-containing Complex Assembly
Response To Cocaine
Positive Regulation Of Apoptotic Process
Positive Regulation Of JUN Kinase Activity
Ephrin Receptor Signaling Pathway
Positive Regulation Of Axonogenesis
Regulation Of Small GTPase Mediated Signal Transduction
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Positive Regulation Of Dendritic Spine Morphogenesis
Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Regulation Of ERK1 And ERK2 Cascade
Protein Localization To Membrane
Activation Of GTPase Activity
NMDA Selective Glutamate Receptor Signaling Pathway
Positive Regulation Of Schwann Cell Chemotaxis
Regulation Of Dopaminergic Neuron Differentiation
Regulation Of Modification Of Postsynaptic Actin Cytoskeleton
Neuron Projection Extension
Regulation Of Non-canonical Wnt Signaling Pathway
G2/M Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Dephosphorylation
Ubiquitin-dependent Protein Catabolic Process
Signal Transduction
Viral Process
Wnt Signaling Pathway
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Destabilization
Mammary Gland Epithelial Cell Proliferation
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Regulation Of Circadian Rhythm
Positive Regulation Of Circadian Rhythm
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA-binding Transcription Factor Activity
Post-translational Protein Modification
Positive Regulation Of Proteolysis
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Rhythmic Process
T Cell Receptor Signaling Pathway
Stress-activated MAPK Cascade
Branching Involved In Mammary Gland Duct Morphogenesis
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Proteasomal Protein Catabolic Process
Interleukin-1-mediated Signaling Pathway
Protein K48-linked Ubiquitination
Cellular Response To Organic Cyclic Compound
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways
NRAGE signals death through JNK
Rho GTPase cycle
EPHB-mediated forward signaling
EPH-ephrin mediated repulsion of cells
G alpha (12/13) signalling events
Activated NTRK2 signals through CDK5
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
Vpu mediated degradation of CD4
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of PLK1 Activity at G2/M Transition
FCERI mediated NF-kB activation
Deactivation of the beta-catenin transactivating complex
Circadian Clock
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Emphysema annual change measurement in smokers (percent low attenuation area) (
31324189
)
Renal sinus fat (
22044751
)
Waist circumference (
28552196
)
Diastolic blood pressure (
30224653
)
Red blood cell count (
29403010
)
Red cell distribution width (
32888494
)
Smoking status (ever vs never smokers) (
30643258
)
Interacting Genes
33 interacting genes:
ABCA1
ANK1
BTRC
CAMK2G
CD44
CDC42
CSNK1A1
EFNB1
EPHA2
FNDC3B
HRAS
MAPK8IP1
MAPK8IP2
MYC
NME1
OSBPL1A
PARD3
PPP1R9B
PPP2CA
PRKCA
PRKCB
PRKCD
PRKCE
PRKCG
PRKCZ
RAC1
RHOA
SRC
SRSF5
SYCP1
UBC
YWHAG
ZKSCAN4
82 interacting genes:
AGO2
AMER1
ATF4
AXIN1
AXIN2
BORA
CCND1
CCNE1
CDC25A
CDC34
CDK1
CENPW
CHPF
CHUK
CP
CTNNB1
CUL1
DBN1
DEPTOR
DLGAP5
E2F1
FBXW11
FBXW2
FOXO3
FZR1
GHR
GLI2
GLI3
GSK3B
HIPK2
HNRNPC
HNRNPK
HNRNPU
ICE1
IL10RA
JUP
KDR
KMT5A
LPCAT1
MCL1
MDM2
MYB
MYC
NFE2
NFKB1
NFKB2
NFKBIA
NFKBIB
NHSL2
PAQR3
PCDH8
PDCD4
PER2
PLK4
PRDX1
PSMA3
PSMD4
RASSF5
RCAN1
RELA
RNF7
SKP1
SMAD3
SMAD4
SMURF1
SMURF2
SUFU
TACC1
TAZ
TIAM1
TP63
TRIB2
TRIM36
TRIM9
TSPAN15
UBC
UBE2D2
UBE2R2
UBQLN2
WEE1
XRCC1
ZC3H12A
Entrez ID
7074
8945
HPRD ID
02820
04596
Ensembl ID
ENSG00000156299
ENSG00000166167
Uniprot IDs
A0A2X0TW27
Q13009
A0A0S2Z4P6
B2R8L3
B7Z3H4
Q68DS0
Q9Y297
PDB IDs
2D8I
3KZD
3KZE
4GVC
4GVD
4K2O
4K2P
4NXP
4NXQ
4NXR
1P22
2P64
6M90
6M91
6M92
6M93
6M94
6TTU
Enriched GO Terms of Interacting Partners
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