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TIAM1 and NME1
Data Source:
HPRD
(in vivo)
TIAM1
NME1
Description
TIAM Rac1 associated GEF 1
NME/NM23 nucleoside diphosphate kinase 1
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
Microtubule
Plasma Membrane
Cell-cell Junction
Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Ruffle Membrane
Neuronal Cell Body
Dendritic Spine
Cell-cell Contact Zone
Axonal Growth Cone
Main Axon
Synapse
Glutamatergic Synapse
Extrinsic Component Of Postsynaptic Density Membrane
Nucleus
Cytoplasm
Mitochondrial Outer Membrane
Centrosome
Cytosol
Intermediate Filament
Membrane
Ruffle Membrane
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Microtubule Binding
Lipid Binding
Kinase Binding
Receptor Tyrosine Kinase Binding
Magnesium Ion Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
Single-stranded DNA Binding
RNA Binding
Deoxyribonuclease Activity
Nucleoside Diphosphate Kinase Activity
Protein Binding
ATP Binding
GTP Binding
Intermediate Filament Binding
Enzyme Binding
Identical Protein Binding
Gamma-tubulin Binding
Ribosomal Small Subunit Binding
Biological Process
Cardiac Muscle Hypertrophy
Apoptotic Process
Cell-matrix Adhesion
G Protein-coupled Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Positive Regulation Of Cell Population Proliferation
Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Epithelial To Mesenchymal Transition
Cell Migration
Rac Protein Signal Transduction
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Binding
Cellular Protein-containing Complex Assembly
Response To Cocaine
Positive Regulation Of Apoptotic Process
Positive Regulation Of JUN Kinase Activity
Ephrin Receptor Signaling Pathway
Positive Regulation Of Axonogenesis
Regulation Of Small GTPase Mediated Signal Transduction
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Positive Regulation Of Dendritic Spine Morphogenesis
Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Regulation Of ERK1 And ERK2 Cascade
Protein Localization To Membrane
Activation Of GTPase Activity
NMDA Selective Glutamate Receptor Signaling Pathway
Positive Regulation Of Schwann Cell Chemotaxis
Regulation Of Dopaminergic Neuron Differentiation
Regulation Of Modification Of Postsynaptic Actin Cytoskeleton
Neuron Projection Extension
Regulation Of Non-canonical Wnt Signaling Pathway
Negative Regulation Of Myeloid Leukocyte Differentiation
Nucleoside Diphosphate Phosphorylation
GTP Biosynthetic Process
UTP Biosynthetic Process
CTP Biosynthetic Process
DNA Metabolic Process
Endocytosis
Lactation
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Gene Expression
Positive Regulation Of Neuron Projection Development
Response To Amine
Nucleobase-containing Small Molecule Interconversion
Hippocampus Development
Cell Differentiation
Response To Testosterone
Cellular Response To Drug
Regulation Of Apoptotic Process
Positive Regulation Of DNA Binding
Positive Regulation Of Epithelial Cell Proliferation
Response To CAMP
Cellular Response To Glucose Stimulus
Cellular Response To Fatty Acid
Pathways
NRAGE signals death through JNK
Rho GTPase cycle
EPHB-mediated forward signaling
EPH-ephrin mediated repulsion of cells
G alpha (12/13) signalling events
Activated NTRK2 signals through CDK5
Interconversion of nucleotide di- and triphosphates
Drugs
Zinc
2'-Deoxyguanosine-5'-Triphosphate
Selenocysteine
2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate
Adenosine Phosphonoacetic Acid
Stavudine triphosphate
Thymidine-5'- Diphosphate
2'-Deoxyguanosine-5'-Diphosphate
2',3'-dideoxy-3'-fluoro-urididine-5'-diphosphate
Guanosine-5'-Diphosphate
3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate
Zidovudine diphosphate
Copper
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Emphysema annual change measurement in smokers (percent low attenuation area) (
31324189
)
Renal sinus fat (
22044751
)
Waist circumference (
28552196
)
Bipolar disorder (
31043756
)
Conjunctival UV autofluorescence (CUVAF) (
25590795
)
Metabolite levels (
23823483
)
Interacting Genes
33 interacting genes:
ABCA1
ANK1
BTRC
CAMK2G
CD44
CDC42
CSNK1A1
EFNB1
EPHA2
FNDC3B
HRAS
MAPK8IP1
MAPK8IP2
MYC
NME1
OSBPL1A
PARD3
PPP1R9B
PPP2CA
PRKCA
PRKCB
PRKCD
PRKCE
PRKCG
PRKCZ
RAC1
RHOA
SRC
SRSF5
SYCP1
UBC
YWHAG
ZKSCAN4
31 interacting genes:
APEX1
AURKA
CCND3
FBXO24
FXR2
GORASP2
ITGB1
KSR1
LNX1
MIF
NIF3L1
NME2
NME3
NME4
NTAQ1
NUTF2
PID1
POLR1C
PRUNE1
RAC1
RORA
RORB
RRAD
SET
SMARCD1
SOX30
SREK1IP1
TERF1
TIAM1
TNPO2
TNPO3
Entrez ID
7074
4830
HPRD ID
02820
01131
Ensembl ID
ENSG00000156299
ENSG00000239672
Uniprot IDs
A0A2X0TW27
Q13009
A0A384MTW7
P15531
PDB IDs
2D8I
3KZD
3KZE
4GVC
4GVD
4K2O
4K2P
4NXP
4NXQ
4NXR
1JXV
1UCN
2HVD
2HVE
3L7U
4ENO
5UI4
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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