TIAM1 and SRSF5

Data Source:
BioGRID (two hybrid)

		TIAM1	SRSF5
Description		TIAM Rac1 associated GEF 1	serine and arginine rich splicing factor 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Microtubule Plasma Membrane Cell-cell Junction Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane Neuronal Cell Body Dendritic Spine Cell-cell Contact Zone Axonal Growth Cone Main Axon Synapse Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane	Nucleoplasm Nucleolus Cytosol Nuclear Speck
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Microtubule Binding Lipid Binding Kinase Binding Receptor Tyrosine Kinase Binding	RNA Binding MRNA Binding Protein Binding Protein Kinase B Binding
	Biological Process	Cardiac Muscle Hypertrophy Apoptotic Process Cell-matrix Adhesion G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Cell Migration Rac Protein Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Protein Binding Cellular Protein-containing Complex Assembly Response To Cocaine Positive Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Ephrin Receptor Signaling Pathway Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Dendritic Spine Morphogenesis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of ERK1 And ERK2 Cascade Protein Localization To Membrane Activation Of GTPase Activity NMDA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Schwann Cell Chemotaxis Regulation Of Dopaminergic Neuron Differentiation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Neuron Projection Extension Regulation Of Non-canonical Wnt Signaling Pathway	MRNA Splicing, Via Spliceosome MRNA Splice Site Selection MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing Cellular Response To Insulin Stimulus Positive Regulation Of RNA Splicing Regulation Of Cell Cycle Liver Regeneration
Pathways		NRAGE signals death through JNK Rho GTPase cycle EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events Activated NTRK2 signals through CDK5	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Renal sinus fat ( 22044751) Waist circumference ( 28552196)	Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		33 interacting genes: ABCA1 ANK1 BTRC CAMK2G CD44 CDC42 CSNK1A1 EFNB1 EPHA2 FNDC3B HRAS MAPK8IP1 MAPK8IP2 MYC NME1 OSBPL1A PARD3 PPP1R9B PPP2CA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ RAC1 RHOA SRC SRSF5 SYCP1 UBC YWHAG ZKSCAN4	20 interacting genes: CALM1 CCR2 CD101 CLK1 DYRK1A HIPK3 MAPK14 MAPK6 OLFM2 PPARGC1A RPS6KA1 SMURF1 SNRPF SREK1 SRPK1 SRPK2 SRSF1 TIAM1 TNK2 ZRSR2
Entrez ID		7074	6430
HPRD ID		02820	02948
Ensembl ID		ENSG00000156299	ENSG00000100650
Uniprot IDs		A0A2X0TW27 Q13009	A0A024R6D8 Q13243 Q86U32
PDB IDs		2D8I 3KZD 3KZE 4GVC 4GVD 4K2O 4K2P 4NXP 4NXQ 4NXR
Enriched GO Terms of Interacting Partners?
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