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TIAM1 and MAPK8IP1
Data Source:
HPRD
(in vivo)
TIAM1
MAPK8IP1
Description
TIAM Rac1 associated GEF 1
mitogen-activated protein kinase 8 interacting protein 1
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
Microtubule
Plasma Membrane
Cell-cell Junction
Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Ruffle Membrane
Neuronal Cell Body
Dendritic Spine
Cell-cell Contact Zone
Axonal Growth Cone
Main Axon
Synapse
Glutamatergic Synapse
Extrinsic Component Of Postsynaptic Density Membrane
Nucleus
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Mitochondrial Membrane
Dendritic Growth Cone
Axonal Growth Cone
Cell Body
Dentate Gyrus Mossy Fiber
Synapse
Perinuclear Region Of Cytoplasm
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Microtubule Binding
Lipid Binding
Kinase Binding
Receptor Tyrosine Kinase Binding
Protein Kinase Inhibitor Activity
MAP-kinase Scaffold Activity
Protein Binding
JUN Kinase Binding
Kinesin Binding
Mitogen-activated Protein Kinase Kinase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Biological Process
Cardiac Muscle Hypertrophy
Apoptotic Process
Cell-matrix Adhesion
G Protein-coupled Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Positive Regulation Of Cell Population Proliferation
Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Epithelial To Mesenchymal Transition
Cell Migration
Rac Protein Signal Transduction
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Binding
Cellular Protein-containing Complex Assembly
Response To Cocaine
Positive Regulation Of Apoptotic Process
Positive Regulation Of JUN Kinase Activity
Ephrin Receptor Signaling Pathway
Positive Regulation Of Axonogenesis
Regulation Of Small GTPase Mediated Signal Transduction
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Positive Regulation Of Dendritic Spine Morphogenesis
Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Regulation Of ERK1 And ERK2 Cascade
Protein Localization To Membrane
Activation Of GTPase Activity
NMDA Selective Glutamate Receptor Signaling Pathway
Positive Regulation Of Schwann Cell Chemotaxis
Regulation Of Dopaminergic Neuron Differentiation
Regulation Of Modification Of Postsynaptic Actin Cytoskeleton
Neuron Projection Extension
Regulation Of Non-canonical Wnt Signaling Pathway
Regulation Of Transcription, DNA-templated
JUN Phosphorylation
Vesicle-mediated Transport
Negative Regulation Of JUN Kinase Activity
Regulation Of JNK Cascade
Positive Regulation Of JNK Cascade
Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
NRAGE signals death through JNK
Rho GTPase cycle
EPHB-mediated forward signaling
EPH-ephrin mediated repulsion of cells
G alpha (12/13) signalling events
Activated NTRK2 signals through CDK5
Drugs
Pyrazolanthrone
6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE
N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE
5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE
Anthralin
Diseases
GWAS
Emphysema annual change measurement in smokers (percent low attenuation area) (
31324189
)
Renal sinus fat (
22044751
)
Waist circumference (
28552196
)
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Axial length (
24144296
)
HDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
Interacting Genes
33 interacting genes:
ABCA1
ANK1
BTRC
CAMK2G
CD44
CDC42
CSNK1A1
EFNB1
EPHA2
FNDC3B
HRAS
MAPK8IP1
MAPK8IP2
MYC
NME1
OSBPL1A
PARD3
PPP1R9B
PPP2CA
PRKCA
PRKCB
PRKCD
PRKCE
PRKCG
PRKCZ
RAC1
RHOA
SRC
SRSF5
SYCP1
UBC
YWHAG
ZKSCAN4
26 interacting genes:
AKT1
APP
ARHGEF28
DUSP16
EGFR
ERBB2
KLC1
LRP1
LRP2
LRP8
MAP2K7
MAP3K10
MAP3K11
MAP3K12
MAP3K13
MAP3K7
MAPK8
MAPK8IP2
MAPK8IP3
MAPK9
PARK7
PAX2
RECQL5
SNCA
TIAM1
VRK2
Entrez ID
7074
9479
HPRD ID
02820
05223
Ensembl ID
ENSG00000156299
ENSG00000121653
Uniprot IDs
A0A2X0TW27
Q13009
Q6NUQ9
Q9UQF2
PDB IDs
2D8I
3KZD
3KZE
4GVC
4GVD
4K2O
4K2P
4NXP
4NXQ
4NXR
2G01
2GMX
2H96
3OXI
3PTG
3VUD
3VUG
3VUH
3VUI
3VUK
3VUL
3VUM
4E73
4G1W
4H39
4HYS
4HYU
4IZY
5LW1
6FUZ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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