BTRC and TP63

Data Source:
BioGRID (enzymatic study)

		BTRC	TP63
Description		beta-transducin repeat containing E3 ubiquitin protein ligase	tumor protein p63
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GO Annotations	Cellular Component	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Rough Endoplasmic Reticulum Dendrite Protein-containing Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Ligase Activity Protein Phosphorylated Amino Acid Binding Protein Dimerization Activity Ubiquitin Protein Ligase Activity Ubiquitin Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding Chromatin Binding Damaged DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Metal Ion Binding WW Domain Binding MDM2/MDM4 Family Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Protein Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Signal Transduction Viral Process Wnt Signaling Pathway Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Mammary Gland Epithelial Cell Proliferation NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Post-translational Protein Modification Positive Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Rhythmic Process T Cell Receptor Signaling Pathway Stress-activated MAPK Cascade Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Interleukin-1-mediated Signaling Pathway Protein K48-linked Ubiquitination Cellular Response To Organic Cyclic Compound Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin Protein Ligase Activity	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Establishment Of Planar Polarity Epithelial Cell Development Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Apoptotic Process Notch Signaling Pathway Spermatogenesis Ectoderm And Mesoderm Interaction Cell Aging Cell Population Proliferation Proximal/distal Pattern Formation Multicellular Organism Aging Epidermal Cell Division Regulation Of Epidermal Cell Division Positive Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Polarized Epithelial Cell Differentiation Hair Follicle Morphogenesis Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Post-anal Tail Morphogenesis Odontogenesis Of Dentin-containing Tooth Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skin Morphogenesis Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Female Genitalia Morphogenesis Protein Tetramerization Neuron Apoptotic Process Cloacal Septation Prostatic Bud Formation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Establishment Of Skin Barrier Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Somatic Stem Cell Population Maintenance Cranial Skeletal System Development Positive Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Mesoderm Development Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Deactivation of the beta-catenin transactivating complex Circadian Clock Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Neddylation Interleukin-1 signaling Antigen processing: Ubiquitination & Proteasome degradation	Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases			Limb-mammary syndrome ADULT syndrome Split-hand/foot malformation (SHFM) Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Ectrodactyly-ectodermal dysplasia cleft-palate syndrome (EEC syndrome) Ankyloblepharon-ctodermal defects-cleft lip/palate (AEC) syndrome and Rapp-Hodgkin syndrome
GWAS		Diastolic blood pressure ( 30224653) Red blood cell count ( 29403010) Red cell distribution width ( 32888494) Smoking status (ever vs never smokers) ( 30643258)	Acute lymphoblastic leukemia (childhood) ( 22076464) Bladder cancer ( 24163127 20972438) Brain imaging ( 20100581) Chlamydia trachomatis PorB antibody levels ( 33204752) Circulating leptin levels in high cardiovascular risk ( 31766143) Cleft lip with or without cleft palate ( 28054174) Cutaneous squamous cell carcinoma ( 32041948) EGFR mutation-positive lung adenocarcinoma ( 27501781) Lung adenocarcinoma ( 28604730 22797724 20871597) Lung cancer ( 28604730 21725308 23143601 24880342) Lung cancer in never smokers ( 31009812) Metabolite levels ( 23823483) Non-small cell lung cancer ( 31326317) Orofacial clefts ( 28054174) Pancreatic cancer ( 29422604 26098869) Postoperative stroke after cardiac surgery ( 30678657) Psoriasis ( 25903422) Psoriasis vulgaris ( 26626624) Squamous cell carcinoma ( 26829030) Systemic lupus erythematosus ( 28714469) Urinary bladder cancer ( 20348956 18794855)
Interacting Genes		82 interacting genes: AGO2 AMER1 ATF4 AXIN1 AXIN2 BORA CCND1 CCNE1 CDC25A CDC34 CDK1 CENPW CHPF CHUK CP CTNNB1 CUL1 DBN1 DEPTOR DLGAP5 E2F1 FBXW11 FBXW2 FOXO3 FZR1 GHR GLI2 GLI3 GSK3B HIPK2 HNRNPC HNRNPK HNRNPU ICE1 IL10RA JUP KDR KMT5A LPCAT1 MCL1 MDM2 MYB MYC NFE2 NFKB1 NFKB2 NFKBIA NFKBIB NHSL2 PAQR3 PCDH8 PDCD4 PER2 PLK4 PRDX1 PSMA3 PSMD4 RASSF5 RCAN1 RELA RNF7 SKP1 SMAD3 SMAD4 SMURF1 SMURF2 SUFU TACC1 TAZ TIAM1 TP63 TRIB2 TRIM36 TRIM9 TSPAN15 UBC UBE2D2 UBE2R2 UBQLN2 WEE1 XRCC1 ZC3H12A	41 interacting genes: BAG6 BTRC CCNC CDC20 CDKN2A COPS6 CSNK2A1 CSNK2A2 CSNK2B DAXX EMX1 EP300 GCGR GRB2 HIPK2 HNRNPAB HP HPX ITCH ITIH4 KAT2B MCRS1 MDM4 NIPSNAP3A ORM1 PELI1 PELI2 PIN1 PINX1 PML PPP1R13B PPP2R5A RACK1 RCHY1 SCAF4 SLC35A3 TP53 TP73 UBASH3A UBE2I WT1
Entrez ID		8945	8626
HPRD ID		04596	04469
Ensembl ID		ENSG00000166167	ENSG00000073282
Uniprot IDs		A0A0S2Z4P6 B2R8L3 B7Z3H4 Q68DS0 Q9Y297	A0A0S2Z4N5 A0A0S2Z4N6 A0A141PNN3 A0A141PNN4 B7Z8X6 C9D7D0 Q9H3D4
PDB IDs		1P22 2P64 6M90 6M91 6M92 6M93 6M94 6TTU	1RG6 2NB1 2RMN 2Y9T 2Y9U 3QYM 3QYN 3US0 3US1 3US2 3ZY0 3ZY1 4A9Z 6FGN 6RU6 6RU7 6RU8
Enriched GO Terms of Interacting Partners?
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