TIAM1 and EFNB1

Data Source:
HPRD (in vivo, in vitro)

		TIAM1	EFNB1
Description		TIAM Rac1 associated GEF 1	ephrin B1
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GO Annotations	Cellular Component	Nucleus Cytosol Microtubule Plasma Membrane Cell-cell Junction Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane Neuronal Cell Body Dendritic Spine Cell-cell Contact Zone Axonal Growth Cone Main Axon Synapse Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Raft Synapse Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Microtubule Binding Lipid Binding Kinase Binding Receptor Tyrosine Kinase Binding	Protein Binding Ephrin Receptor Binding
	Biological Process	Cardiac Muscle Hypertrophy Apoptotic Process Cell-matrix Adhesion G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Cell Migration Rac Protein Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Protein Binding Cellular Protein-containing Complex Assembly Response To Cocaine Positive Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Ephrin Receptor Signaling Pathway Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Dendritic Spine Morphogenesis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of ERK1 And ERK2 Cascade Protein Localization To Membrane Activation Of GTPase Activity NMDA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Schwann Cell Chemotaxis Regulation Of Dopaminergic Neuron Differentiation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Neuron Projection Extension Regulation Of Non-canonical Wnt Signaling Pathway	Neural Crest Cell Migration Cell Adhesion Cell-cell Signaling Axon Guidance Embryonic Pattern Specification T Cell Costimulation Positive Regulation Of T Cell Proliferation Ephrin Receptor Signaling Pathway
Pathways		NRAGE signals death through JNK Rho GTPase cycle EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events Activated NTRK2 signals through CDK5	EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs
Diseases			Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Renal sinus fat ( 22044751) Waist circumference ( 28552196)
Interacting Genes		33 interacting genes: ABCA1 ANK1 BTRC CAMK2G CD44 CDC42 CSNK1A1 EFNB1 EPHA2 FNDC3B HRAS MAPK8IP1 MAPK8IP2 MYC NME1 OSBPL1A PARD3 PPP1R9B PPP2CA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ RAC1 RHOA SRC SRSF5 SYCP1 UBC YWHAG ZKSCAN4	18 interacting genes: ANKRD46 CAPN10 CUL3 DNAJC5 EPHA3 EPHB1 EPHB2 GRIP1 MYC NCK2 PICK1 PTPN13 RGS3 SDCBP SORBS1 SRC TIAM1 YWHAQ
Entrez ID		7074	1947
HPRD ID		02820	02072
Ensembl ID		ENSG00000156299	ENSG00000090776
Uniprot IDs		A0A2X0TW27 Q13009	P98172
PDB IDs		2D8I 3KZD 3KZE 4GVC 4GVD 4K2O 4K2P 4NXP 4NXQ 4NXR	6THG
Enriched GO Terms of Interacting Partners?
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