NASP and H1-1

Data Source:
HPRD (in vitro, in vivo)

		NASP	H1-1
Description		nuclear autoantigenic sperm protein	H1.1 linker histone, cluster member
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm
	Molecular Function	Protein Binding Histone Binding	Double-stranded DNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Blastocyst Development DNA Replication DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Male Gonad Development Protein Transport Response To Testosterone CENP-A Containing Nucleosome Assembly Histone Exchange	Nucleosome Assembly Spermatogenesis Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination
Pathways			Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Blood metabolite levels ( 24816252) Blood protein levels ( 28240269) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		26 interacting genes: ASF1A CDC42 H1-1 H1-2 H3-4 H3-5 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 HDAC6 LUC7L2 MTNR1A PTK2 TERF2 TERF2IP ULK2	52 interacting genes: AEBP2 APP CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK2 CDK4 CDK5 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L1 NAP1L4 NASP NSD3 PAK4 PARP1 PARP3 PELP1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 RPS6KA5 SET SNCA SUZ12 TAF1 TERF1 TERF2IP TLK1
Entrez ID		4678	3024
HPRD ID		04423	00820
Ensembl ID		ENSG00000132780	ENSG00000124610
Uniprot IDs		P49321 Q5T626	Q02539
PDB IDs
Enriched GO Terms of Interacting Partners?
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