H1-1 and PARP3

Data Source:
BioGRID (enzymatic study)

		H1-1	PARP3
Description		H1.1 linker histone, cluster member	poly(ADP-ribose) polymerase family member 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm	Nucleoplasm Nucleolus Cytoplasm Centriole Nuclear Body Site Of Double-strand Break Intercellular Bridge
	Molecular Function	Double-stranded DNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding	Catalytic Activity NAD+ ADP-ribosyltransferase Activity Protein Binding NAD DNA ADP-ribosyltransferase Activity Protein ADP-ribosylase Activity
	Biological Process	Nucleosome Assembly Spermatogenesis Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination	Telomere Maintenance DNA Repair Double-strand Break Repair Protein ADP-ribosylation DNA ADP-ribosylation Negative Regulation Of Isotype Switching Positive Regulation Of DNA Ligation Regulation Of Mitotic Spindle Organization Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Protein Mono-ADP-ribosylation Negative Regulation Of Telomerase RNA Reverse Transcriptase Activity Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs			2-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one -ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-one N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE Olaparib Rucaparib
Diseases
GWAS
Interacting Genes		52 interacting genes: AEBP2 APP CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK2 CDK4 CDK5 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L1 NAP1L4 NASP NSD3 PAK4 PARP1 PARP3 PELP1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 RPS6KA5 SET SNCA SUZ12 TAF1 TERF1 TERF2IP TLK1	4 interacting genes: APP H1-1 MEOX2 PARP1
Entrez ID		3024	10039
HPRD ID		00820	06370
Ensembl ID		ENSG00000124610	ENSG00000041880
Uniprot IDs		Q02539	A0A024R318 Q9Y6F1
PDB IDs			2EOC 3C49 3C4H 3CE0 3FHB 4GV0 4GV2 4GV4 4L6Z 4L70 4L7L 4L7N 4L7O 4L7P 4L7R 4L7U
Enriched GO Terms of Interacting Partners?
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