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H1-1 and CCNA1
Data Source:
BioGRID
(enzymatic study)
H1-1
CCNA1
Description
H1.1 linker histone, cluster member
cyclin A1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleosome
Euchromatin
Nucleus
Nucleoplasm
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Microtubule Cytoskeleton
Cyclin A1-CDK2 Complex
Cyclin A2-CDK2 Complex
Molecular Function
Double-stranded DNA Binding
Protein Binding
Chromatin DNA Binding
Nucleosomal DNA Binding
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Biological Process
Nucleosome Assembly
Spermatogenesis
Nucleosome Positioning
Chromosome Condensation
Negative Regulation Of Chromatin Silencing
Negative Regulation Of DNA Recombination
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Male Meiosis I
Spermatogenesis
Protein Deubiquitination
Mitotic Cell Cycle Phase Transition
Cell Division
Pathways
Apoptosis induced DNA fragmentation
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
G0 and Early G1
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
Telomere Extension By Telomerase
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Ub-specific processing proteases
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G1/S-Specific Transcription
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A/B1/B2 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases
GWAS
Cocaine dependence (
31212010
)
Nickel levels (
26025379
)
Interacting Genes
52 interacting genes:
AEBP2
APP
CCNA1
CCNA2
CCNB1
CCND2
CCNE1
CDK1
CDK2
CDK4
CDK5
CDK6
CDK7
CDKN1B
CRP
CTCFL
EED
EHMT2
EP300
EZH2
GADD45A
GZMA
IRAK4
KAT2B
LIMK1
LIMK2
LOX
NAP1L1
NAP1L4
NASP
NSD3
PAK4
PARP1
PARP3
PELP1
PRDM1
PRKCA
PRKCB
PRKCD
PRKCE
PRKCZ
PRKDC
PTMA
RBBP4
RPS6KA5
SET
SNCA
SUZ12
TAF1
TERF1
TERF2IP
TLK1
35 interacting genes:
ARID2
BRCA1
BRCA2
CABLES1
CDC20
CDC25A
CDK1
CDK2
CDKN1A
CDKN1B
CKS1B
CKS2
CUX1
E2F1
GPS2
H1-1
H1-5
H2BC1
INCA1
KLHDC9
MCM4
MCM6
MYBL2
NPAT
PGR
PROCA1
RACK1
RB1
RBL1
RBL2
RBM4
RPA1
SP1
SRC
XRCC6
Entrez ID
3024
8900
HPRD ID
00820
04946
Ensembl ID
ENSG00000124610
ENSG00000133101
Uniprot IDs
Q02539
A0A140VJG0
P78396
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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