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H1-1 and PARP1
Data Source:
BioGRID
(enzymatic study)
H1-1
PARP1
Description
H1.1 linker histone, cluster member
poly(ADP-ribose) polymerase 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleosome
Euchromatin
Nucleus
Nucleoplasm
Chromosome, Telomeric Region
Nucleus
Nuclear Envelope
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Mitochondrion
Membrane
Nuclear Body
Protein-containing Complex
Protein-DNA Complex
Site Of Double-strand Break
Site Of DNA Damage
Molecular Function
Double-stranded DNA Binding
Protein Binding
Chromatin DNA Binding
Nucleosomal DNA Binding
DNA Binding
RNA Binding
NAD+ ADP-ribosyltransferase Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
Enzyme Binding
Protein Kinase Binding
Estrogen Receptor Binding
Identical Protein Binding
Histone Deacetylase Binding
Protein N-terminus Binding
NAD Binding
R-SMAD Binding
NAD DNA ADP-ribosyltransferase Activity
Protein ADP-ribosylase Activity
Biological Process
Nucleosome Assembly
Spermatogenesis
Nucleosome Positioning
Chromosome Condensation
Negative Regulation Of Chromatin Silencing
Negative Regulation Of DNA Recombination
Negative Regulation Of Transcription By RNA Polymerase II
Nucleotide-excision Repair, DNA Damage Recognition
Nucleotide-excision Repair, DNA Duplex Unwinding
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Double-strand Break Repair
Transcription By RNA Polymerase II
Protein ADP-ribosylation
Apoptotic Process
Cellular Response To DNA Damage Stimulus
Mitochondrion Organization
Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Gamma Radiation
Positive Regulation Of Cardiac Muscle Hypertrophy
Regulation Of SMAD Protein Complex Assembly
Protein Autoprocessing
Peptidyl-serine ADP-ribosylation
Peptidyl-glutamic Acid Poly-ADP-ribosylation
Signal Transduction Involved In Regulation Of Gene Expression
Macrophage Differentiation
DNA ADP-ribosylation
Mitochondrial DNA Metabolic Process
Cellular Response To Insulin Stimulus
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Nucleotide-excision Repair, DNA Incision
Cellular Response To Oxidative Stress
Cellular Response To UV
Protein Modification Process
DNA Damage Response, Detection Of DNA Damage
Mitochondrial DNA Repair
Regulation Of DNA Methylation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Catalytic Activity
Positive Regulation Of Mitochondrial Depolarization
Positive Regulation Of SMAD Protein Signal Transduction
Protein Poly-ADP-ribosylation
Protein Auto-ADP-ribosylation
Global Genome Nucleotide-excision Repair
Cellular Response To Zinc Ion
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Neuron Death
Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Single Strand Break Repair
Regulation Of Cellular Protein Localization
Response To Aldosterone
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Cellular Response To Amyloid-beta
Positive Regulation Of Myofibroblast Differentiation
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
ATP Generation From Poly-ADP-D-ribose
Positive Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of ATP Biosynthetic Process
Pathways
Apoptosis induced DNA fragmentation
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
POLB-Dependent Long Patch Base Excision Repair
vRNA Synthesis
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SUMOylation of DNA damage response and repair proteins
HDR through MMEJ (alt-NHEJ)
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Drugs
Theophylline
Zinc
Carba-nicotinamide-adenine-dinucleotide
NU1025
Nicotinamide
2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone
3-Methoxybenzamide
2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide
3,4-Dihydro-5-Methyl-Isoquinolinone
2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide
6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE
Veliparib
A-620223
5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE
Olaparib
Talazoparib
Niraparib
Rucaparib
Iniparib
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Coronary artery disease (
29212778
)
Leukocyte telomere length (
32109421
31171785
)
Melanoma (
21983785
)
Mild to moderate chronic kidney disease (
31178898
)
Nevus count or cutaneous melanoma (
32341527
30429480
)
Platelet count (
29403010
)
Telomere length (
29151059
)
Interacting Genes
52 interacting genes:
AEBP2
APP
CCNA1
CCNA2
CCNB1
CCND2
CCNE1
CDK1
CDK2
CDK4
CDK5
CDK6
CDK7
CDKN1B
CRP
CTCFL
EED
EHMT2
EP300
EZH2
GADD45A
GZMA
IRAK4
KAT2B
LIMK1
LIMK2
LOX
NAP1L1
NAP1L4
NASP
NSD3
PAK4
PARP1
PARP3
PELP1
PRDM1
PRKCA
PRKCB
PRKCD
PRKCE
PRKCZ
PRKDC
PTMA
RBBP4
RPS6KA5
SET
SNCA
SUZ12
TAF1
TERF1
TERF2IP
TLK1
105 interacting genes:
APTX
ATM
BCL2
BLID
BRD7
BUB3
CASP1
CASP3
CASP7
CASP8
CD86
CDKN1A
CENPA
CENPB
CREBBP
CTCF
CTSB
CTSG
DTX2
DUX4
E2F1
ERCC6
ERG
ETS1
FOXO1
GTF2F1
GZMB
GZMM
H1-0
H1-1
H1-2
H1-5
H2AC18
H2BC4
H3-3A
H3-4
H3C1
H4C3
HDAC1
HDAC3
HIPK2
HMGA1
HMGN1
HMGN2
HMGN4
HOXB7
HPF1
HSPA2
IKBKG
IL24
KAT2B
KLF5
LIG3
LZTR1
MACROH2A1
MED14
MED6
MORC2
MTA3
MYBL2
NAT10
NCL
NCOA6
NEDD8
NFATC1
NFKB1
NPM1
NRF1
OVOL2
PARP2
PARP3
PCNA
PIAS4
POLA1
POLA2
POU2F1
PRKDC
RARA
RASL10B
RBM14
RELA
RNF144A
RNF168
RPS3A
RXRA
SENP1
SENP3
SIRT1
SP1
SREK1
SUMO2
SUPT16H
SWAP70
TCF3
TCF4
THRSP
TP53
UBE2I
WRN
XRCC1
XRCC5
XRCC6
ZBTB16
ZBTB9
ZNF423
Entrez ID
3024
142
HPRD ID
00820
01435
Ensembl ID
ENSG00000124610
ENSG00000143799
Uniprot IDs
Q02539
A0A024R3T8
P09874
PDB IDs
1UK0
1UK1
1WOK
2COK
2CR9
2CS2
2DMJ
2JVN
2L30
2L31
2N8A
2RCW
2RD6
2RIQ
3GJW
3GN7
3L3L
3L3M
3OD8
3ODA
3ODC
3ODE
4AV1
4DQY
4GV7
4HHY
4HHZ
4L6S
4OPX
4OQA
4OQB
4PJT
4R5W
4R6E
4RV6
4UND
4UXB
4XHU
4ZZZ
5A00
5DS3
5HA9
5KPN
5KPO
5KPP
5KPQ
5WRQ
5WRY
5WRZ
5WS0
5WS1
5WTC
5XSR
5XST
5XSU
6BHV
6GHK
6NRF
6NRG
6NRH
6NRI
6NRJ
6NTU
6VKK
6VKO
6VKQ
6XVW
Enriched GO Terms of Interacting Partners
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