H1-1 and PAK4

Data Source:
BioGRID (enzymatic study)

		H1-1	PAK4
Description		H1.1 linker histone, cluster member	p21 (RAC1) activated kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm	Cytoplasm Golgi Apparatus Adherens Junction Focal Adhesion
	Molecular Function	Double-stranded DNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Involved In Cell-cell Adhesion Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Nucleosome Assembly Spermatogenesis Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination	Regulation Of Cell Growth Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Cell Cycle Signal Transduction Cell Migration Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Angiogenesis Dendritic Spine Development Cellular Response To Organic Cyclic Compound Cell-cell Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Activation of RAC1
Drugs			Fostamatinib
Diseases
GWAS
Interacting Genes		52 interacting genes: AEBP2 APP CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK2 CDK4 CDK5 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L1 NAP1L4 NASP NSD3 PAK4 PARP1 PARP3 PELP1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 RPS6KA5 SET SNCA SUZ12 TAF1 TERF1 TERF2IP TLK1	25 interacting genes: APP CDC42 DGCR6L DLST FBXO25 FGFR2 G6PD GATAD2A GRB2 H1-1 INKA1 ITGAV ITGB5 LIMK1 POT1 PPARG RAN RHOU SH3RF2 SRPK1 SRPK2 TERF1 YWHAG YWHAQ YWHAZ
Entrez ID		3024	10298
HPRD ID		00820	05675
Ensembl ID		ENSG00000124610	ENSG00000130669
Uniprot IDs		Q02539	A0A024R0J1 A0A024R0L8 O96013
PDB IDs			2BVA 2CDZ 2J0I 2OV2 2Q0N 2X4Z 4APP 4FIE 4FIF 4FIG 4FIH 4FII 4FIJ 4JDH 4JDI 4JDJ 4JDK 4L67 4NJD 4O0V 4O0X 4O0Y 4XBR 4XBU 5BMS 5I0B 5UPK 5UPL 5VED 5VEE 5VEF 5XVA 5XVF 5XVG 5ZJW 6WLX 6WLY
Enriched GO Terms of Interacting Partners?
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