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H1-1 and PRKCZ
Data Source:
BioGRID
(enzymatic study)
H1-1
PRKCZ
Description
H1.1 linker histone, cluster member
protein kinase C zeta
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleosome
Euchromatin
Nucleus
Nucleoplasm
Stress Fiber
Nuclear Envelope
Cytoplasm
Endosome
Microtubule Organizing Center
Cytosol
Plasma Membrane
Cell-cell Junction
Bicellular Tight Junction
Postsynaptic Density
Membrane
Apical Plasma Membrane
Nuclear Matrix
Cell Junction
Cell Leading Edge
Vesicle
Myelin Sheath Abaxonal Region
Axon Hillock
Membrane Raft
Apical Cortex
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Molecular Function
Double-stranded DNA Binding
Protein Binding
Chromatin DNA Binding
Nucleosomal DNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Calcium-dependent Protein Kinase C Activity
Protein Binding
ATP Binding
Potassium Channel Regulator Activity
Protein Kinase Binding
Phospholipase Binding
Insulin Receptor Substrate Binding
Protein-containing Complex Binding
Metal Ion Binding
14-3-3 Protein Binding
Biological Process
Nucleosome Assembly
Spermatogenesis
Nucleosome Positioning
Chromosome Condensation
Negative Regulation Of Chromatin Silencing
Negative Regulation Of DNA Recombination
Microtubule Cytoskeleton Organization
Positive Regulation Of Cell-matrix Adhesion
Protein Phosphorylation
Inflammatory Response
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Long-term Memory
Positive Regulation Of Cell Population Proliferation
Cell Migration
Peptidyl-serine Phosphorylation
Establishment Of Cell Polarity
Negative Regulation Of Protein-containing Complex Assembly
Activation Of Phospholipase D Activity
Activation Of Protein Kinase B Activity
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-13 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-5 Production
Cellular Response To Insulin Stimulus
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Positive Regulation Of T-helper 2 Cell Differentiation
Negative Regulation Of Insulin Receptor Signaling Pathway
Positive Regulation Of Insulin Receptor Signaling Pathway
Vesicle Transport Along Microtubule
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Protein Transport
Negative Regulation Of Hydrolase Activity
Membrane Depolarization
Membrane Hyperpolarization
Long-term Synaptic Potentiation
Positive Regulation Of ERK1 And ERK2 Cascade
Protein Kinase C Signaling
Protein Localization To Plasma Membrane
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Neuron Projection Extension
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways
Apoptosis induced DNA fragmentation
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
GPVI-mediated activation cascade
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
VEGFR2 mediated cell proliferation
RHO GTPases Activate NADPH Oxidases
Estrogen-stimulated signaling through PRKCZ
Estrogen-stimulated signaling through PRKCZ
Drugs
Tamoxifen
Diseases
GWAS
Body mass index (
26426971
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
General risk tolerance (MTAG) (
30643258
)
Height (
20881960
)
Response to antipsychotic treatment in schizophrenia (reasoning) (
21107309
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
52 interacting genes:
AEBP2
APP
CCNA1
CCNA2
CCNB1
CCND2
CCNE1
CDK1
CDK2
CDK4
CDK5
CDK6
CDK7
CDKN1B
CRP
CTCFL
EED
EHMT2
EP300
EZH2
GADD45A
GZMA
IRAK4
KAT2B
LIMK1
LIMK2
LOX
NAP1L1
NAP1L4
NASP
NSD3
PAK4
PARP1
PARP3
PELP1
PRDM1
PRKCA
PRKCB
PRKCD
PRKCE
PRKCZ
PRKDC
PTMA
RBBP4
RPS6KA5
SET
SNCA
SUZ12
TAF1
TERF1
TERF2IP
TLK1
88 interacting genes:
ADAP1
ADCY5
AFAP1
AKT1
AKT3
BLVRA
BTK
C1QBP
CASP3
CASP6
CASP7
CASP8
CASP9
CCDC115
CDC42
CHAT
CSNK2B
DAPK3
DENND5A
EGFR
FADD
FEZ1
FEZ2
FRS2
FYN
GLRX3
GRB14
GRM5
GSK3A
GSK3B
H1-1
H1-5
HABP4
HDAC6
HRAS
IKBKB
IL4R
IRAK1
IRS1
IRS4
JAK1
KRT10
LRRK2
MAP2K1
MAP2K5
MAPK1
MAPK3
MAPK7
MAPT
MARCKS
MBP
NCF1
NCL
NCOA3
NFATC2
NMT2
NUMB
PARD6A
PARD6B
PARD6G
PAWR
PDLIM7
PDPK1
PEBP1
PIAS4
PPP1R14A
PPP3CA
PRG2
PRKCA
PRKCD
PSEN1
RAF1
RELA
RHOA
SLC39A1
SP1
SQSTM1
SRC
STAT6
STUB1
TIAM1
TRAF6
UTP14A
WWC1
YWHAB
YWHAQ
YWHAZ
ZNF71
Entrez ID
3024
5590
HPRD ID
00820
01504
Ensembl ID
ENSG00000124610
ENSG00000067606
Uniprot IDs
Q02539
Q05513
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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