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H1-1 and NSD3
Data Source:
BioGRID
(two hybrid)
H1-1
NSD3
Description
H1.1 linker histone, cluster member
nuclear receptor binding SET domain protein 3
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleosome
Euchromatin
Nucleus
Nucleoplasm
Chromatin
Nucleus
Nucleoplasm
Molecular Function
Double-stranded DNA Binding
Protein Binding
Chromatin DNA Binding
Nucleosomal DNA Binding
Protein Binding
Histone-lysine N-methyltransferase Activity
Metal Ion Binding
Histone Methyltransferase Activity (H3-K36 Specific)
Transcription Regulator Activator Activity
Biological Process
Nucleosome Assembly
Spermatogenesis
Nucleosome Positioning
Chromosome Condensation
Negative Regulation Of Chromatin Silencing
Negative Regulation Of DNA Recombination
Regulation Of Transcription, DNA-templated
Histone H3-K36 Methylation
Histone Methylation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Histone H3-K36 Trimethylation
Pathways
Apoptosis induced DNA fragmentation
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Interacting Genes
52 interacting genes:
AEBP2
APP
CCNA1
CCNA2
CCNB1
CCND2
CCNE1
CDK1
CDK2
CDK4
CDK5
CDK6
CDK7
CDKN1B
CRP
CTCFL
EED
EHMT2
EP300
EZH2
GADD45A
GZMA
IRAK4
KAT2B
LIMK1
LIMK2
LOX
NAP1L1
NAP1L4
NASP
NSD3
PAK4
PARP1
PARP3
PELP1
PRDM1
PRKCA
PRKCB
PRKCD
PRKCE
PRKCZ
PRKDC
PTMA
RBBP4
RPS6KA5
SET
SNCA
SUZ12
TAF1
TERF1
TERF2IP
TLK1
42 interacting genes:
AKT1
ATM
BCAR3
CASP8
CBLC
CBX3
CBX5
CDKN2A
CHEK2
DAXX
DOCK7
ESR1
ETV3
FGFR4
GLIS2
GLYR1
H1-1
H3-5
H3C1
H4C1
HOXC4
MLLT6
MNDA
MYC
NFIC
PAX2
PPM1D
RB1CC1
SEPTIN6
SLU7
SOX3
SOX4
SPAG8
STAC3
TCF3
TEAD2
TERT
TGFB1
TRIM55
TRIM63
UBE2I
ZNF557
Entrez ID
3024
54904
HPRD ID
00820
06155
Ensembl ID
ENSG00000124610
ENSG00000147548
Uniprot IDs
Q02539
Q9BZ95
PDB IDs
2DAQ
2NCZ
2ND1
4GND
4GNE
4GNF
4GNG
4RXJ
5UPD
6CEN
6G24
6G25
6G27
6G29
6G2B
6G2C
6G2E
6G2F
6G2O
6G3P
6G3T
7CRP
7CRQ
7CRR
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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