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PRKCZ and CASP3
Data Source:
HPRD
(in vivo, in vitro)
PRKCZ
CASP3
Description
protein kinase C zeta
caspase 3
Image
No pdb structure
GO Annotations
Cellular Component
Stress Fiber
Nuclear Envelope
Cytoplasm
Endosome
Microtubule Organizing Center
Cytosol
Plasma Membrane
Cell-cell Junction
Bicellular Tight Junction
Postsynaptic Density
Membrane
Apical Plasma Membrane
Nuclear Matrix
Cell Junction
Cell Leading Edge
Vesicle
Myelin Sheath Abaxonal Region
Axon Hillock
Membrane Raft
Apical Cortex
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Death-inducing Signaling Complex
Neuronal Cell Body
Membrane Raft
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Calcium-dependent Protein Kinase C Activity
Protein Binding
ATP Binding
Potassium Channel Regulator Activity
Protein Kinase Binding
Phospholipase Binding
Insulin Receptor Substrate Binding
Protein-containing Complex Binding
Metal Ion Binding
14-3-3 Protein Binding
Protease Binding
Aspartic-type Endopeptidase Activity
Cysteine-type Endopeptidase Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Death Receptor Binding
Protein Binding
Peptidase Activity
Phospholipase A2 Activator Activity
Protein-containing Complex Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Biological Process
Microtubule Cytoskeleton Organization
Positive Regulation Of Cell-matrix Adhesion
Protein Phosphorylation
Inflammatory Response
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Long-term Memory
Positive Regulation Of Cell Population Proliferation
Cell Migration
Peptidyl-serine Phosphorylation
Establishment Of Cell Polarity
Negative Regulation Of Protein-containing Complex Assembly
Activation Of Phospholipase D Activity
Activation Of Protein Kinase B Activity
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-13 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-5 Production
Cellular Response To Insulin Stimulus
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Positive Regulation Of T-helper 2 Cell Differentiation
Negative Regulation Of Insulin Receptor Signaling Pathway
Positive Regulation Of Insulin Receptor Signaling Pathway
Vesicle Transport Along Microtubule
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Protein Transport
Negative Regulation Of Hydrolase Activity
Membrane Depolarization
Membrane Hyperpolarization
Long-term Synaptic Potentiation
Positive Regulation Of ERK1 And ERK2 Cascade
Protein Kinase C Signaling
Protein Localization To Plasma Membrane
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Neuron Projection Extension
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of T-helper 2 Cell Cytokine Production
Luteolysis
Response To Hypoxia
B Cell Homeostasis
Apoptotic DNA Fragmentation
Proteolysis
Apoptotic Process
Cellular Response To DNA Damage Stimulus
Axonal Fasciculation
Heart Development
Sensory Perception Of Sound
Learning Or Memory
Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Response To UV
Response To Glucose
Response To X-ray
Regulation Of Macroautophagy
Protein Processing
Cytokine-mediated Signaling Pathway
Hippocampus Development
Neuron Differentiation
Keratinocyte Differentiation
Erythrocyte Differentiation
Platelet Formation
Negative Regulation Of B Cell Proliferation
Regulation Of Protein Stability
Response To Cobalt Ion
Response To Estradiol
Response To Lipopolysaccharide
Glial Cell Apoptotic Process
Response To Tumor Necrosis Factor
Response To Nicotine
Hippo Signaling
Wound Healing
Response To Drug
Response To Hydrogen Peroxide
T Cell Homeostasis
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Response To Amino Acid
Positive Regulation Of Neuron Apoptotic Process
Cell Fate Commitment
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Activated T Cell Proliferation
Response To Antibiotic
Neurotrophin TRK Receptor Signaling Pathway
Striated Muscle Cell Differentiation
Response To Glucocorticoid
Neuron Apoptotic Process
Anterior Neural Tube Closure
Leukocyte Apoptotic Process
Cellular Response To Staurosporine
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Execution Phase Of Apoptosis
Positive Regulation Of Amyloid-beta Formation
Pathways
GPVI-mediated activation cascade
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
VEGFR2 mediated cell proliferation
RHO GTPases Activate NADPH Oxidases
Estrogen-stimulated signaling through PRKCZ
Estrogen-stimulated signaling through PRKCZ
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
Apoptotic cleavage of cellular proteins
SMAC, XIAP-regulated apoptotic response
Apoptosis induced DNA fragmentation
Degradation of the extracellular matrix
Signaling by Hippo
NADE modulates death signalling
Stimulation of the cell death response by PAK-2p34
Caspase-mediated cleavage of cytoskeletal proteins
Apoptotic cleavage of cell adhesion proteins
Caspase activation via Dependence Receptors in the absence of ligand
Caspase activation via Dependence Receptors in the absence of ligand
Other interleukin signaling
Drugs
Tamoxifen
Pamidronic acid
Acetylsalicylic acid
Minocycline
5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid
Emricasan
Incadronic acid
2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID
methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate
1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE
[N-(3-dibenzylcarbamoyl-oxiranecarbonyl)-hydrazino]-acetic acid
4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID
(1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
(1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide
Glycyrrhizic acid
Diseases
GWAS
Body mass index (
26426971
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
General risk tolerance (MTAG) (
30643258
)
Height (
20881960
)
Response to antipsychotic treatment in schizophrenia (reasoning) (
21107309
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Blood protein levels (
28240269
)
Hippocampal volume in Alzheimer's disease dementia (
29274321
)
Kawasaki disease (
33106546
)
Interacting Genes
88 interacting genes:
ADAP1
ADCY5
AFAP1
AKT1
AKT3
BLVRA
BTK
C1QBP
CASP3
CASP6
CASP7
CASP8
CASP9
CCDC115
CDC42
CHAT
CSNK2B
DAPK3
DENND5A
EGFR
FADD
FEZ1
FEZ2
FRS2
FYN
GLRX3
GRB14
GRM5
GSK3A
GSK3B
H1-1
H1-5
HABP4
HDAC6
HRAS
IKBKB
IL4R
IRAK1
IRS1
IRS4
JAK1
KRT10
LRRK2
MAP2K1
MAP2K5
MAPK1
MAPK3
MAPK7
MAPT
MARCKS
MBP
NCF1
NCL
NCOA3
NFATC2
NMT2
NUMB
PARD6A
PARD6B
PARD6G
PAWR
PDLIM7
PDPK1
PEBP1
PIAS4
PPP1R14A
PPP3CA
PRG2
PRKCA
PRKCD
PSEN1
RAF1
RELA
RHOA
SLC39A1
SP1
SQSTM1
SRC
STAT6
STUB1
TIAM1
TRAF6
UTP14A
WWC1
YWHAB
YWHAQ
YWHAZ
ZNF71
157 interacting genes:
ACIN1
ADD1
AFP
AIFM1
AKAP8
AKT1
APAF1
APP
AR
ARHGDIA
ARHGDIB
ARNT
ATG4D
ATN1
BCAP31
BCAR1
BCL2
BECN1
BID
BIRC2
BIRC3
BIRC5
BIRC6
BIRC7
BLM
BMX
BRCA1
CAD
CASP10
CASP2
CASP4
CASP6
CASP7
CASP8
CASP9
CAST
CDC27
CDC42
CDH1
CDK11B
CDKN1A
CFLAR
COPS6
CRYAB
CTNNB1
CTTN
DBNL
DCC
DCTN1
DEDD
DFFA
DSG3
EIF2AK2
EIF2S1
EIF3J
EIF4B
EIF4G2
FYN
GATA1
GLRX
GMNN
GOLGA3
GORASP1
GRIPAP1
GSN
GZMB
HCLS1
HIP1
HMGB1
HNRNPU
HSPD1
HSPE1
HTT
IL16
IL18
KCNIP3
KRT18
LMNB1
LYN
MAP4K1
MAPK8
MAPK8IP3
MAPK9
MAPT
MCL1
MDC1
MDM2
MDM4
MEF2A
MET
MLH1
MYL3
NDUFS1
NEDD4
NFE2L2
NMT2
PAK2
PARG
PARP1
PDE10A
PDE5A
PICALM
PIP5K1A
PKN1
PKN2
PLA2G4A
PLA2G4B
PPP3CA
PRKCQ
PRKCZ
PRKDC
PSEN1
PSEN2
PSIP1
PSME3
PTBP1
PTGES3
PTMA
PXN
RABEP1
RAC1
RAD51
RASA1
RB1
RFC1
RNF2
ROCK1
SARS2
SLK
SNRNP70
SOCS5
SOHLH1
SP1
SPTAN1
SREBF2
SRF
SRP72
STAT1
STK24
STK3
STK4
TFAP2A
TGM2
THAP11
TNFSF10
TOP1
TRAF1
TRAF3
UBE4B
USO1
VAV1
VIM
WEE1
XIAP
YWHAE
YWHAG
ZBTB16
Entrez ID
5590
836
HPRD ID
01504
02799
Ensembl ID
ENSG00000067606
ENSG00000164305
Uniprot IDs
Q05513
P42574
PDB IDs
1CP3
1GFW
1I3O
1NME
1NMQ
1NMS
1PAU
1QX3
1RE1
1RHJ
1RHK
1RHM
1RHQ
1RHR
1RHU
2C1E
2C2K
2C2M
2C2O
2CDR
2CJX
2CJY
2CNK
2CNL
2CNN
2CNO
2DKO
2H5I
2H5J
2H65
2J30
2J31
2J32
2J33
2XYG
2XYH
2XYP
2XZD
2XZT
2Y0B
3DEH
3DEI
3DEJ
3DEK
3EDQ
3GJQ
3GJR
3GJS
3GJT
3H0E
3ITN
3KJF
3PCX
3PD0
3PD1
4DCJ
4DCO
4DCP
4EHA
4EHD
4EHF
4EHH
4EHK
4EHL
4EHN
4JJE
4JQY
4JQZ
4JR0
4PRY
4PS0
4QTX
4QTY
4QU0
4QU5
4QU8
4QU9
4QUA
4QUB
4QUD
4QUE
4QUG
4QUH
4QUI
4QUJ
4QUL
5I9B
5I9T
5IAB
5IAE
5IAG
5IAJ
5IAK
5IAN
5IAR
5IAS
5IBC
5IBP
5IBR
5IC4
Enriched GO Terms of Interacting Partners
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