PRKCZ and ADCY5

Data Source:
HPRD (in vitro)

		PRKCZ	ADCY5
Description		protein kinase C zeta	adenylate cyclase 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nuclear Envelope Cytoplasm Endosome Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Bicellular Tight Junction Postsynaptic Density Membrane Apical Plasma Membrane Nuclear Matrix Cell Junction Cell Leading Edge Vesicle Myelin Sheath Abaxonal Region Axon Hillock Membrane Raft Apical Cortex Perinuclear Region Of Cytoplasm Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Plasma Membrane Integral Component Of Plasma Membrane Cilium Integral Component Of Membrane Intermediate Filament Cytoskeleton
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Protein Kinase Binding Phospholipase Binding Insulin Receptor Substrate Binding Protein-containing Complex Binding Metal Ion Binding 14-3-3 Protein Binding	Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Metal Ion Binding Scaffold Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Positive Regulation Of Cell-matrix Adhesion Protein Phosphorylation Inflammatory Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Long-term Memory Positive Regulation Of Cell Population Proliferation Cell Migration Peptidyl-serine Phosphorylation Establishment Of Cell Polarity Negative Regulation Of Protein-containing Complex Assembly Activation Of Phospholipase D Activity Activation Of Protein Kinase B Activity Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Cellular Response To Insulin Stimulus Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Vesicle Transport Along Microtubule Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Transport Negative Regulation Of Hydrolase Activity Membrane Depolarization Membrane Hyperpolarization Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Protein Localization To Plasma Membrane Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Neuron Projection Extension Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of T-helper 2 Cell Cytokine Production	G Protein-coupled Adenosine Receptor Signaling Pathway Renal Water Homeostasis CAMP Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Locomotory Behavior Activation Of Protein Kinase A Activity Neuromuscular Process Controlling Balance Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cellular Response To Glucagon Stimulus Cellular Response To Forskolin
Pathways		GPVI-mediated activation cascade TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Estrogen-stimulated signaling through PRKCZ Estrogen-stimulated signaling through PRKCZ	Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis
Drugs		Tamoxifen	Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Height ( 20881960) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Birth weight ( 23202124 31043758 27680694 20372150) Body mass index ( 25673413) Chronic kidney disease ( 26420894) Chronic obstructive pulmonary disease ( 30804561) Chronotype ( 30696823) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Gestational age at birth (maternal effect) ( 28877031) Glycated hemoglobin levels ( 28898252) Glycemic traits (pleiotropy) ( 31021400) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Homeostasis model assessment of beta-cell function ( 20081858) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) PR interval ( 32439900) Pulse pressure ( 30224653) Refractive error ( 32231278) Total cholesterol levels ( 29083408) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 22885922 24509480 30054458 22693455 29358691 30297969 28254843 26818947 32499647 28869590) White blood cell count ( 32888494)
Interacting Genes		88 interacting genes: ADAP1 ADCY5 AFAP1 AKT1 AKT3 BLVRA BTK C1QBP CASP3 CASP6 CASP7 CASP8 CASP9 CCDC115 CDC42 CHAT CSNK2B DAPK3 DENND5A EGFR FADD FEZ1 FEZ2 FRS2 FYN GLRX3 GRB14 GRM5 GSK3A GSK3B H1-1 H1-5 HABP4 HDAC6 HRAS IKBKB IL4R IRAK1 IRS1 IRS4 JAK1 KRT10 LRRK2 MAP2K1 MAP2K5 MAPK1 MAPK3 MAPK7 MAPT MARCKS MBP NCF1 NCL NCOA3 NFATC2 NMT2 NUMB PARD6A PARD6B PARD6G PAWR PDLIM7 PDPK1 PEBP1 PIAS4 PPP1R14A PPP3CA PRG2 PRKCA PRKCD PSEN1 RAF1 RELA RHOA SLC39A1 SP1 SQSTM1 SRC STAT6 STUB1 TIAM1 TRAF6 UTP14A WWC1 YWHAB YWHAQ YWHAZ ZNF71	7 interacting genes: ADCY2 GNAI1 GNAS PRKACA PRKCA PRKCZ RGS2
Entrez ID		5590	111
HPRD ID		01504	08973
Ensembl ID		ENSG00000067606	ENSG00000173175
Uniprot IDs		Q05513	A0A384P5Q5 B3KWA8 B7Z2C7 O95622
PDB IDs
Enriched GO Terms of Interacting Partners?
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