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PRKCZ and YWHAB
Data Source:
BioGRID
(affinity chromatography technology, two hybrid)
HPRD
(in vivo, in vitro)
PRKCZ
YWHAB
Description
protein kinase C zeta
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Image
No pdb structure
GO Annotations
Cellular Component
Stress Fiber
Nuclear Envelope
Cytoplasm
Endosome
Microtubule Organizing Center
Cytosol
Plasma Membrane
Cell-cell Junction
Bicellular Tight Junction
Postsynaptic Density
Membrane
Apical Plasma Membrane
Nuclear Matrix
Cell Junction
Cell Leading Edge
Vesicle
Myelin Sheath Abaxonal Region
Axon Hillock
Membrane Raft
Apical Cortex
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Nucleus
Cytoplasm
Mitochondrion
Vacuolar Membrane
Cytosol
Focal Adhesion
Membrane
Transcription Repressor Complex
Melanosome
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Calcium-dependent Protein Kinase C Activity
Protein Binding
ATP Binding
Potassium Channel Regulator Activity
Protein Kinase Binding
Phospholipase Binding
Insulin Receptor Substrate Binding
Protein-containing Complex Binding
Metal Ion Binding
14-3-3 Protein Binding
Protein Kinase Inhibitor Activity
Protein Binding
Protein C-terminus Binding
Enzyme Binding
Protein Domain Specific Binding
Identical Protein Binding
Histone Deacetylase Binding
Protein-containing Complex Binding
Cadherin Binding
Phosphoserine Residue Binding
Phosphoprotein Binding
Biological Process
Microtubule Cytoskeleton Organization
Positive Regulation Of Cell-matrix Adhesion
Protein Phosphorylation
Inflammatory Response
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Long-term Memory
Positive Regulation Of Cell Population Proliferation
Cell Migration
Peptidyl-serine Phosphorylation
Establishment Of Cell Polarity
Negative Regulation Of Protein-containing Complex Assembly
Activation Of Phospholipase D Activity
Activation Of Protein Kinase B Activity
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-13 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-5 Production
Cellular Response To Insulin Stimulus
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Positive Regulation Of T-helper 2 Cell Differentiation
Negative Regulation Of Insulin Receptor Signaling Pathway
Positive Regulation Of Insulin Receptor Signaling Pathway
Vesicle Transport Along Microtubule
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Protein Transport
Negative Regulation Of Hydrolase Activity
Membrane Depolarization
Membrane Hyperpolarization
Long-term Synaptic Potentiation
Positive Regulation Of ERK1 And ERK2 Cascade
Protein Kinase C Signaling
Protein Localization To Plasma Membrane
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Neuron Projection Extension
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of T-helper 2 Cell Cytokine Production
MAPK Cascade
Negative Regulation Of Protein Kinase Activity
Protein Targeting
Viral Process
Negative Regulation Of Protein Dephosphorylation
Hippo Signaling
Positive Regulation Of Catalytic Activity
Regulation Of MRNA Stability
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Cytoplasmic Sequestering Of Protein
Membrane Organization
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways
GPVI-mediated activation cascade
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
VEGFR2 mediated cell proliferation
RHO GTPases Activate NADPH Oxidases
Estrogen-stimulated signaling through PRKCZ
Estrogen-stimulated signaling through PRKCZ
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
MTOR signalling
mTORC1-mediated signalling
Frs2-mediated activation
Frs2-mediated activation
ARMS-mediated activation
Signaling by Hippo
Rap1 signalling
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Regulation of localization of FOXO transcription factors
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by MRAS-complex mutants
Drugs
Tamoxifen
Copper
Phenethyl Isothiocyanate
Diseases
GWAS
Body mass index (
26426971
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
General risk tolerance (MTAG) (
30643258
)
Height (
20881960
)
Response to antipsychotic treatment in schizophrenia (reasoning) (
21107309
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Blood protein levels (
30072576
)
Breakfast cereal skipping frequency (
31190057
)
Breakfast skipping (
31190057
)
Mean platelet volume (
32888494
)
Interacting Genes
88 interacting genes:
ADAP1
ADCY5
AFAP1
AKT1
AKT3
BLVRA
BTK
C1QBP
CASP3
CASP6
CASP7
CASP8
CASP9
CCDC115
CDC42
CHAT
CSNK2B
DAPK3
DENND5A
EGFR
FADD
FEZ1
FEZ2
FRS2
FYN
GLRX3
GRB14
GRM5
GSK3A
GSK3B
H1-1
H1-5
HABP4
HDAC6
HRAS
IKBKB
IL4R
IRAK1
IRS1
IRS4
JAK1
KRT10
LRRK2
MAP2K1
MAP2K5
MAPK1
MAPK3
MAPK7
MAPT
MARCKS
MBP
NCF1
NCL
NCOA3
NFATC2
NMT2
NUMB
PARD6A
PARD6B
PARD6G
PAWR
PDLIM7
PDPK1
PEBP1
PIAS4
PPP1R14A
PPP3CA
PRG2
PRKCA
PRKCD
PSEN1
RAF1
RELA
RHOA
SLC39A1
SP1
SQSTM1
SRC
STAT6
STUB1
TIAM1
TRAF6
UTP14A
WWC1
YWHAB
YWHAQ
YWHAZ
ZNF71
142 interacting genes:
ABL1
ADAM22
AFDN
AKAP13
ALS2
APP
ATP5F1A
BAD
BAX
BCL2L11
BCR
BID
BRAF
C1QBP
CAMK2A
CAMK2B
CBL
CDC25A
CDC25B
CDC25C
CDK11B
CDK14
CDKN1B
CHAF1A
CRTC2
CSNK2A1
DAPK1
DHX15
DYRK1A
EDC3
EGFR
EPB41
EPB41L1
EPB41L3
ERRFI1
EXO1
FER
FRMD6
GAPVD1
GEM
H3C1
HDAC5
HES1
HSP90AB1
HSPA1A
HSPA1B
HSPA5
HSPB1
IGF1R
IKBKB
ING1
INSR
IRS1
IRS2
ITGB1
ITGB4
KANK1
KCNK15
KCNK3
KCNK9
KIAA0930
KIF1C
KIF23
KIF5B
KLC1
KRT18
LARP1
LYST
MAP3K3
MAPK7
MAPT
MARK2
MARK4
MDM4
MICALL1
MINK1
MLXIP
MPRIP
MST1R
MTNR1A
MTNR1B
OSBPL3
PARD3
PARD6B
PDCL2
PDE3B
PI4KB
PIK3R2
PIK3R4
PRKCD
PRKCG
PRKCZ
PRPF6
PTPN3
RABGEF1
RACGAP1
RADIL
RAF1
RAI14
RALGPS2
RASGRF1
RGS3
RGS7
RIN1
RIOK1
RMDN3
RNPS1
RPS6KA1
SAMSN1
SKP2
SLC4A7
SLC8A1
SLC8A2
SLC8A3
SLC9A1
SNCA
SNRNP200
SON
SRC
SRRM2
SRSF10
SRSF3
STK38
STK38L
TESK1
TESK2
TH
TJP2
TNFAIP3
TPD52L1
TSC1
TSC2
TUBB
UBC
UCP2
UCP3
WDR77
WEE1
YWHAE
YWHAG
ZFP36
ZFP36L1
Entrez ID
5590
7529
HPRD ID
01504
03184
Ensembl ID
ENSG00000067606
ENSG00000166913
Uniprot IDs
Q05513
P31946
V9HWD6
PDB IDs
2BQ0
2C23
4DNK
5N10
6A5Q
6BYK
6GN0
6GN8
6GNJ
6GNK
6GNN
6HEP
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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