GZMA and H1-1

Data Source:
BioGRID (enzymatic study)

		GZMA	H1-1
Description		granzyme A	H1.1 linker histone, cluster member
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Nucleus	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Protein Homodimerization Activity	Double-stranded DNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	Apoptotic Process Immune Response Response To Bacterium Cytolysis Negative Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Oxidoreductase Activity Proteolysis Involved In Cellular Protein Catabolic Process Pyroptosis Granzyme-mediated Programmed Cell Death Signaling Pathway Cytotoxic T Cell Pyroptotic Process	Nucleosome Assembly Spermatogenesis Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination
Pathways			Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS
Interacting Genes		17 interacting genes: ACTG1 APEX1 GOLGA2 H1-1 H2BC21 HDC HMGB2 HNRNPK HSP90AA1 HSPA4 LMNA LMNB1 NCL NDUFS3 SET XRCC5 XRCC6	52 interacting genes: AEBP2 APP CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK2 CDK4 CDK5 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L1 NAP1L4 NASP NSD3 PAK4 PARP1 PARP3 PELP1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 RPS6KA5 SET SNCA SUZ12 TAF1 TERF1 TERF2IP TLK1
Entrez ID		3001	3024
HPRD ID		00771	00820
Ensembl ID		ENSG00000145649	ENSG00000124610
Uniprot IDs		P12544	Q02539
PDB IDs		1HF1 1OP8 1ORF
Enriched GO Terms of Interacting Partners?
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