GZMA and NCL

Data Source:
HPRD (in vitro)

		GZMA	NCL
Description		granzyme A	nucleolin
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GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Nucleus	Nucleus Nucleoplasm Spliceosomal Complex Chromosome Nucleolus Cell Cortex Membrane Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Protein Homodimerization Activity	RNA Binding Protein Binding Protein C-terminus Binding Telomeric DNA Binding Identical Protein Binding DNA Topoisomerase Binding MRNA 5'-UTR Binding
	Biological Process	Apoptotic Process Immune Response Response To Bacterium Cytolysis Negative Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Oxidoreductase Activity Proteolysis Involved In Cellular Protein Catabolic Process Pyroptosis Granzyme-mediated Programmed Cell Death Signaling Pathway Cytotoxic T Cell Pyroptotic Process	Angiogenesis Negative Regulation Of Translation Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Pathways			Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder ( 23728934) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Eating disorders (purging via substances) ( 23568457) Height ( 31562340) Noise-induced hearing loss ( 26121033)
Interacting Genes		17 interacting genes: ACTG1 APEX1 GOLGA2 H1-1 H2BC21 HDC HMGB2 HNRNPK HSP90AA1 HSPA4 LMNA LMNB1 NCL NDUFS3 SET XRCC5 XRCC6	57 interacting genes: ADAP1 ADAP2 CD3E CDK1 CDKN2A CLK1 CSNK2A1 CSNK2A2 DUX4 ERG ESR1 ETS1 FMR1 GRB2 GZF1 GZMA H1-2 H2AC20 H2AX H2BC21 H3-4 HMGA1 IL7R LINC01554 MDC1 MDK MDM2 MYB MYBL1 NBN NDRG1 NPM1 NR3C1 PARP1 POLR1G PPARGC1A PPM1D PRKCZ PRMT5 PTGS1 RAD51 S100A11 SREK1 SRPK2 SSB STAU1 SUMO2 TERF2 TERT TOP1 TP53 VHL XRCC6 YWHAQ ZFP36 ZFP41 ZNF689
Entrez ID		3001	4691
HPRD ID		00771	01245
Ensembl ID		ENSG00000145649	ENSG00000115053
Uniprot IDs		P12544	B3KM80 P19338
PDB IDs		1HF1 1OP8 1ORF	2FC8 2FC9 2KRR
Enriched GO Terms of Interacting Partners?
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