GZMA and NDUFS3

Data Source:
BioGRID (enzymatic study)

		GZMA	NDUFS3
Description		granzyme A	NADH:ubiquinone oxidoreductase core subunit S3
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GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Nucleus	Mitochondrion Mitochondrial Respiratory Chain Complex I Mitochondrial Matrix Nuclear Body Mitochondrial Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Protein Homodimerization Activity	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity
	Biological Process	Apoptotic Process Immune Response Response To Bacterium Cytolysis Negative Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Oxidoreductase Activity Proteolysis Involved In Cellular Protein Catabolic Process Pyroptosis Granzyme-mediated Programmed Cell Death Signaling Pathway Cytotoxic T Cell Pyroptotic Process	Mitochondrial Electron Transport, NADH To Ubiquinone Substantia Nigra Development Negative Regulation Of Cell Growth Mitochondrial Respiratory Chain Complex I Assembly Reactive Oxygen Species Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS			Adult body size ( 32376654) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 20935630) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Fruit consumption ( 32066663) Height ( 28552196) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mood instability ( 31168069) Neuroticism ( 29255261) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698)
Interacting Genes		17 interacting genes: ACTG1 APEX1 GOLGA2 H1-1 H2BC21 HDC HMGB2 HNRNPK HSP90AA1 HSPA4 LMNA LMNB1 NCL NDUFS3 SET XRCC5 XRCC6	4 interacting genes: GZMA NDUFA5 RASL10B TMEM11
Entrez ID		3001	4722
HPRD ID		00771	10355
Ensembl ID		ENSG00000145649	ENSG00000213619
Uniprot IDs		P12544	O75489
PDB IDs		1HF1 1OP8 1ORF	5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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