GMNN and UBE2S

Number of citations of the paper that reports this interaction (PubMedID 29875408)
7

Data Source:
BioGRID (enzymatic study)

		GMNN	UBE2S
Description		geminin DNA replication inhibitor	ubiquitin conjugating enzyme E2 S
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cell Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding Repressing Transcription Factor Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Anaphase-promoting Complex Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Negative Regulation Of DNA Replication Animal Organ Morphogenesis Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-dependent DNA Replication	Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Cell Division Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways		CDT1 association with the CDC6:ORC:origin complex Activation of the pre-replicative complex	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)
Interacting Genes		27 interacting genes: ARNT AURKA CASP3 CDKN1A CDKN2A CDT1 CSNK2A1 FZR1 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KAT7 MCM6 NCF1 PHC1 REPIN1 SCMH1 SIX3 SMARCA4 UBE2C UBE2S ZNF439	40 interacting genes: AKT1 ANAPC1 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 APP ATXN3 BIRC2 CDC16 CDC20 CDC23 CDC27 CTNNB1 CYLD FBXO5 FZR1 GMNN HERC1 LINC00839 MDM2 OTUB1 OTUD7B PRKN PTEN RBCK1 RNF7 STAMBP UBA1 UBA6 UBB UBC UCHL3 USP15 USP2 USP21 USP5 USP7 ZRANB1
Entrez ID		51053	27338
HPRD ID		06783	15603
Ensembl ID		ENSG00000112312	ENSG00000108106
Uniprot IDs		A0A024QZY7 O75496	Q16763
PDB IDs		1T6F 1UII 2LP0 2WVR 4BRY	1ZDN 5BNB 5L9T 6QH3 6QHK
Enriched GO Terms of Interacting Partners?
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