GMNN and IMPDH1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		GMNN	IMPDH1
Description		geminin DNA replication inhibitor	inosine monophosphate dehydrogenase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Extracellular Region Nucleus Cytoplasm Cytosol Secretory Granule Lumen Azurophil Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding Repressing Transcription Factor Binding	Nucleotide Binding Nucleic Acid Binding DNA Binding RNA Binding IMP Dehydrogenase Activity Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Negative Regulation Of DNA Replication Animal Organ Morphogenesis Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-dependent DNA Replication	GMP Biosynthetic Process GTP Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Neutrophil Degranulation Lymphocyte Proliferation Oxidation-reduction Process
Pathways		CDT1 association with the CDC6:ORC:origin complex Activation of the pre-replicative complex	Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis
Drugs			NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine 6-Chloropurine Riboside, 5'-Monophosphate VX-148
Diseases			Leber congenital amaurosis (LCR) Retinitis pigmentosa (RP)
GWAS		Metabolite levels ( 23823483)
Interacting Genes		27 interacting genes: ARNT AURKA CASP3 CDKN1A CDKN2A CDT1 CSNK2A1 FZR1 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KAT7 MCM6 NCF1 PHC1 REPIN1 SCMH1 SIX3 SMARCA4 UBE2C UBE2S ZNF439	2 interacting genes: GMNN HTRA1
Entrez ID		51053	3614
HPRD ID		06783	08853
Ensembl ID		ENSG00000112312	ENSG00000106348
Uniprot IDs		A0A024QZY7 O75496	B3KRZ3 P20839 Q6ZNB1
PDB IDs		1T6F 1UII 2LP0 2WVR 4BRY	1JCN
Enriched GO Terms of Interacting Partners?
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