GMNN and KAT7

Number of citations of the paper that reports this interaction (PubMedID 16428461)
70

Data Source:
BioGRID (enzymatic study)

		GMNN	KAT7
Description		geminin DNA replication inhibitor	lysine acetyltransferase 7
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Histone Acetyltransferase Complex Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding Repressing Transcription Factor Binding	DNA Replication Origin Binding DNA-binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Histone Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Negative Regulation Of DNA Replication Animal Organ Morphogenesis Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-dependent DNA Replication	DNA Replication Regulation Of Transcription, DNA-templated Internal Peptidyl-lysine Acetylation Stress-activated Protein Kinase Signaling Cascade Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Sorbitol Response To Hydroxyurea Response To Actinomycin D Response To Dithiothreitol Response To Anisomycin Positive Regulation Of Histone H4 Acetylation Positive Regulation Of Protein Localization To Nucleus
Pathways		CDT1 association with the CDC6:ORC:origin complex Activation of the pre-replicative complex	HATs acetylate histones
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252)
Interacting Genes		27 interacting genes: ARNT AURKA CASP3 CDKN1A CDKN2A CDT1 CSNK2A1 FZR1 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KAT7 MCM6 NCF1 PHC1 REPIN1 SCMH1 SIX3 SMARCA4 UBE2C UBE2S ZNF439	43 interacting genes: APP AR ATN1 BARD1 CAAP1 CALCOCO2 CBX8 CDC6 CDK11B CEP126 CEP70 CSNK1E DDX11 DVL3 DYNC1I1 GMNN H2AC20 H3C1 H4C1 HAP1 HOOK2 ING4 KATNBL1 KCTD13 LRIF1 MAP2K1 MCM2 NINL ORC1 ORC2 PACSIN1 POLB PPID RGL2 RPS10 SAT1 SEPTIN5 SNAPIN TP53 VIM WDR33 ZBTB8A ZNF165
Entrez ID		51053	11143
HPRD ID		06783	07135
Ensembl ID		ENSG00000112312	ENSG00000136504
Uniprot IDs		A0A024QZY7 O75496	O95251
PDB IDs		1T6F 1UII 2LP0 2WVR 4BRY	5GK9
Enriched GO Terms of Interacting Partners?
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