GMNN and HOXC9

Number of citations of the paper that reports this interaction (PubMedID 14973489)
72

Data Source:
HPRD (in vitro)

		GMNN	HOXC9
Description		geminin DNA replication inhibitor	homeobox C9
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nuclear Chromatin Nucleus Nucleoplasm Aggresome
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding Repressing Transcription Factor Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Replication Negative Regulation Of DNA Replication Animal Organ Morphogenesis Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-dependent DNA Replication	Transcription, DNA-templated Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis
Pathways		CDT1 association with the CDC6:ORC:origin complex Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Heel bone mineral density ( 30598549) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		27 interacting genes: ARNT AURKA CASP3 CDKN1A CDKN2A CDT1 CSNK2A1 FZR1 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KAT7 MCM6 NCF1 PHC1 REPIN1 SCMH1 SIX3 SMARCA4 UBE2C UBE2S ZNF439	16 interacting genes: CBX6 ELAVL2 GMNN GTF2A1L HOXC13 HOXD1 HOXD9 IRF9 LPXN NMI PCGF2 POLR2D POLR3D POU2F1 ZFP36 ZNF384
Entrez ID		51053	3225
HPRD ID		06783	00857
Ensembl ID		ENSG00000112312	ENSG00000180806
Uniprot IDs		A0A024QZY7 O75496	A0A024RAZ6 P31274
PDB IDs		1T6F 1UII 2LP0 2WVR 4BRY	2LP0 2MSY
Enriched GO Terms of Interacting Partners?
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