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CDC20 and UBE2C
Data Source:
BioGRID
(enzymatic study)
CDC20
UBE2C
Description
cell division cycle 20
ubiquitin conjugating enzyme E2 C
Image
GO Annotations
Cellular Component
Spindle Pole
Nucleoplasm
Anaphase-promoting Complex
Centrosome
Spindle
Cytosol
Perinuclear Region Of Cytoplasm
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Plasma Membrane
Molecular Function
Protein Binding
Protein C-terminus Binding
Anaphase-promoting Complex Binding
Enzyme Binding
Histone Deacetylase Binding
Ubiquitin Ligase Activator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin-like Protein Ligase Binding
Ubiquitin Conjugating Enzyme Activity
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Mitotic Sister Chromatid Cohesion
Mitotic Spindle Assembly Checkpoint
Nervous System Development
Positive Regulation Of Cell Population Proliferation
Protein Ubiquitination
Protein Deubiquitination
Cell Differentiation
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Synaptic Plasticity
Regulation Of Meiotic Nuclear Division
Regulation Of Dendrite Development
Cell Division
Positive Regulation Of Synapse Maturation
Mitotic Spindle Assembly
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Exit From Mitosis
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Exit From Mitosis
Cell Division
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Inactivation of APC/C via direct inhibition of the APC/C complex
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
APC/C:Cdc20 mediated degradation of Cyclin B
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of Emi1
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Ub-specific processing proteases
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Antigen processing: Ubiquitination & Proteasome degradation
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) (
27114598
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Height (
31562340
)
Interacting Genes
47 interacting genes:
ANAPC1
ANAPC10
ANAPC11
ANAPC2
ANAPC4
ANAPC7
APP
AURKA
BUB1
BUB1B
CCNA1
CCNA2
CCNB1
CCT5
CDC16
CDC27
CDC6
CDK1
CDR2
CDT1
DCPS
FBXO5
FZR1
HDAC1
HDAC2
HSF1
HSF2
KIF18A
MAD2L1
MAD2L1BP
MAD2L2
NEK2
OTUD7B
PIM1
PTTG1
RASSF1
SIRT2
SOSTDC1
SPATC1
TCP1
TGFBR1
TK1
TP63
TRIP13
UBC
UBE2C
UBE2S
33 interacting genes:
ANAPC11
ANAPC2
AURKA
CCNA2
CCNB1
CDC20
CKAP2
CXCR1
DTX1
ENO2
FBXO5
FZR1
GMNN
ITCH
KLHL2
MAPK7
PCGF3
POLM
PRKN
PSMD4
PTTG1
RAG1
RELA
RNF31
RNF7
TNNC1
TRIM21
TRIM28
TRIM29
TRIM72
UBA1
UBASH3B
UBE3D
Entrez ID
991
11065
HPRD ID
04686
05717
Ensembl ID
ENSG00000117399
ENSG00000175063
Uniprot IDs
Q12834
A0A087WVK1
A0A0A0MSE8
O00762
Q5TZN3
PDB IDs
4GGA
4GGC
4GGD
4N14
5G04
5KHR
5KHU
5LCW
6F0X
6Q6G
6Q6H
1I7K
4YII
5A31
5KHR
5L9U
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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