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CDC20 and TRIP13
Data Source:
BioGRID
(pull down, pull down)
CDC20
TRIP13
Description
cell division cycle 20
thyroid hormone receptor interactor 13
Image
GO Annotations
Cellular Component
Spindle Pole
Nucleoplasm
Anaphase-promoting Complex
Centrosome
Spindle
Cytosol
Perinuclear Region Of Cytoplasm
Male Germ Cell Nucleus
Nucleus
Chromosome
Molecular Function
Protein Binding
Protein C-terminus Binding
Anaphase-promoting Complex Binding
Enzyme Binding
Histone Deacetylase Binding
Ubiquitin Ligase Activator Activity
Transcription Coregulator Activity
Protein Binding
ATP Binding
ATPase Activity
Identical Protein Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Mitotic Sister Chromatid Cohesion
Mitotic Spindle Assembly Checkpoint
Nervous System Development
Positive Regulation Of Cell Population Proliferation
Protein Ubiquitination
Protein Deubiquitination
Cell Differentiation
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Synaptic Plasticity
Regulation Of Meiotic Nuclear Division
Regulation Of Dendrite Development
Cell Division
Positive Regulation Of Synapse Maturation
Mitotic Spindle Assembly
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Oocyte Maturation
Double-strand Break Repair
Regulation Of Transcription, DNA-templated
Transcription By RNA Polymerase II
Mitotic Spindle Assembly Checkpoint
Synaptonemal Complex Assembly
Reciprocal Meiotic Recombination
Male Meiosis I
Female Meiosis I
Spermatogenesis
Spermatid Development
Oogenesis
Meiotic Recombination Checkpoint
Pathways
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Inactivation of APC/C via direct inhibition of the APC/C complex
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
APC/C:Cdc20 mediated degradation of Cyclin B
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of Emi1
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Ub-specific processing proteases
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) (
27114598
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Pancreatic cancer (
25086665
)
Interacting Genes
47 interacting genes:
ANAPC1
ANAPC10
ANAPC11
ANAPC2
ANAPC4
ANAPC7
APP
AURKA
BUB1
BUB1B
CCNA1
CCNA2
CCNB1
CCT5
CDC16
CDC27
CDC6
CDK1
CDR2
CDT1
DCPS
FBXO5
FZR1
HDAC1
HDAC2
HSF1
HSF2
KIF18A
MAD2L1
MAD2L1BP
MAD2L2
NEK2
OTUD7B
PIM1
PTTG1
RASSF1
SIRT2
SOSTDC1
SPATC1
TCP1
TGFBR1
TK1
TP63
TRIP13
UBC
UBE2C
UBE2S
112 interacting genes:
ADAM15
AMDHD2
ANKRD10
ARL11
ARSA
ASB13
BUB1B
C11orf54
C19orf54
C4orf33
CARD14
CD99
CDC20
CDIN1
CEP170B
CFP
CLIP4
COMT
CRMP1
CRYBA2
CYB5R2
DCTN3
DDAH2
DIP2A
DPYSL4
DTX2
EEF2KMT
FBLN5
FBXO8
FNDC3B
GALT
GLYCTK
GPRIN2
GPSM1
HDHD3
IGFN1
IL2RB
INCA1
INTS11
KRTAP12-1
KRTAP12-2
KRTAP12-4
KRTAP26-1
KRTAP3-2
KRTAP6-1
KRTAP6-2
KYAT1
LASP1
LNX1
LOXL4
LRR1
LRRC61
M1AP
MAD2L1
MAD2L1BP
MBLAC1
MEAK7
METTL15
MGAT5B
MORN3
MPPED2
MVP
MYEOV
NIF3L1
NME4
NTAQ1
PARP11
PAX9
PBLD
PCMTD2
PCSK5
PELI1
PLAC8
PLK3
PLSCR3
PLSCR4
POLR2L
PPP2CA
PRKAA2
PRKN
PRR13
PSMB8
QARS1
RBPMS
RHOXF2
RNF4
SCP2
SDCBP
SEC24A
SELENBP1
SEMA3B
SEMA4G
SHARPIN
SIGLEC5
SMUG1
SPRYD7
SSC4D
STAMBP
STAMBPL1
SUMO2
TENT5B
TEX37
THRB
TINAGL1
TNRC6A
TPT1
UBE2I
VDR
VENTX
ZMYM5
ZNF34
ZNF655
Entrez ID
991
9319
HPRD ID
04686
05145
Ensembl ID
ENSG00000117399
ENSG00000071539
Uniprot IDs
Q12834
Q15645
PDB IDs
4GGA
4GGC
4GGD
4N14
5G04
5KHR
5KHU
5LCW
6F0X
6Q6G
6Q6H
5VQ9
5VQA
5WC2
6F0X
6LK0
Enriched GO Terms of Interacting Partners
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