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CDC20 and CCT5
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology)
CDC20
CCT5
Description
cell division cycle 20
chaperonin containing TCP1 subunit 5
Image
GO Annotations
Cellular Component
Spindle Pole
Nucleoplasm
Anaphase-promoting Complex
Centrosome
Spindle
Cytosol
Perinuclear Region Of Cytoplasm
Centrosome
Cytosol
Chaperonin-containing T-complex
Microtubule
Cell Body
Extracellular Exosome
Molecular Function
Protein Binding
Protein C-terminus Binding
Anaphase-promoting Complex Binding
Enzyme Binding
Histone Deacetylase Binding
Ubiquitin Ligase Activator Activity
MRNA 3'-UTR Binding
Protein Binding
ATP Binding
G-protein Beta-subunit Binding
Protein Folding Chaperone
MRNA 5'-UTR Binding
Beta-tubulin Binding
Unfolded Protein Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Mitotic Sister Chromatid Cohesion
Mitotic Spindle Assembly Checkpoint
Nervous System Development
Positive Regulation Of Cell Population Proliferation
Protein Ubiquitination
Protein Deubiquitination
Cell Differentiation
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Synaptic Plasticity
Regulation Of Meiotic Nuclear Division
Regulation Of Dendrite Development
Cell Division
Positive Regulation Of Synapse Maturation
Mitotic Spindle Assembly
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Protein Folding
Binding Of Sperm To Zona Pellucida
Response To Virus
Positive Regulation Of Telomere Maintenance Via Telomerase
Protein Stabilization
Toxin Transport
Positive Regulation Of Establishment Of Protein Localization To Telomere
Positive Regulation Of Protein Localization To Cajal Body
Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Inactivation of APC/C via direct inhibition of the APC/C complex
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
APC/C:Cdc20 mediated degradation of Cyclin B
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of Emi1
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Ub-specific processing proteases
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Antigen processing: Ubiquitination & Proteasome degradation
Prefoldin mediated transfer of substrate to CCT/TriC
Formation of tubulin folding intermediates by CCT/TriC
Folding of actin by CCT/TriC
Association of TriC/CCT with target proteins during biosynthesis
Association of TriC/CCT with target proteins during biosynthesis
BBSome-mediated cargo-targeting to cilium
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs
Diseases
GWAS
Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) (
27114598
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Metabolite levels (
23823483
)
Pain (
22956598
)
Interacting Genes
47 interacting genes:
ANAPC1
ANAPC10
ANAPC11
ANAPC2
ANAPC4
ANAPC7
APP
AURKA
BUB1
BUB1B
CCNA1
CCNA2
CCNB1
CCT5
CDC16
CDC27
CDC6
CDK1
CDR2
CDT1
DCPS
FBXO5
FZR1
HDAC1
HDAC2
HSF1
HSF2
KIF18A
MAD2L1
MAD2L1BP
MAD2L2
NEK2
OTUD7B
PIM1
PTTG1
RASSF1
SIRT2
SOSTDC1
SPATC1
TCP1
TGFBR1
TK1
TP63
TRIP13
UBC
UBE2C
UBE2S
20 interacting genes:
ACTA1
ACTA2
ACTB
CDC20
DUXAP9
ELP1
ERCC6
HDAC3
IMMT
MCPH1
PDCL
SUMO2
SUMO4
TBC1D17
TCP1
TERT
THEG
TP53
XRN1
ZNRD2
Entrez ID
991
22948
HPRD ID
04686
06468
Ensembl ID
ENSG00000117399
ENSG00000150753
Uniprot IDs
Q12834
B4DDU6
B4DX08
B4DYC8
B7ZAR1
E7ENZ3
E9PCA1
P48643
V9HW37
PDB IDs
4GGA
4GGC
4GGD
4N14
5G04
5KHR
5KHU
5LCW
6F0X
6Q6G
6Q6H
5UYX
5UYZ
6NR8
6NR9
6NRA
6NRB
6NRC
6NRD
6QB8
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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