NUAK1 and FBXO25

Data Source:
BioGRID (enzymatic study)

		NUAK1	FBXO25
Description		NUAK family kinase 1	F-box protein 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex
	Molecular Function	P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Actin Binding Ubiquitin-protein Transferase Activity
	Biological Process	Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Adhesion Regulation Of Cell Adhesion Regulation Of Myosin-light-chain-phosphatase Activity Intracellular Signal Transduction Regulation Of Cell Population Proliferation Cellular Response To Glucose Starvation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cellular Senescence	Protein Ubiquitination
Pathways		Regulation of TP53 Activity through Phosphorylation
Drugs		Fostamatinib
Diseases
GWAS		Alzheimer's disease biomarkers ( 23419831) Attention function in attention deficit hyperactive disorder ( 26174813) Brain morphology (MOSTest) ( 32665545) General glucose level in pregnancy (gestational week 30-32) ( 30324795) Lateral ventricular volume in normal aging ( 30258056) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Two-hour glucose in pregnancy (gestational week 30-32) ( 30324795)	Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		5 interacting genes: APP CASP6 FBXO25 LATS1 PPP1CC	82 interacting genes: ANKRD13A APLF AXL BMX BRME1 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		9891	26260
HPRD ID		12171	16439
Ensembl ID		ENSG00000074590	ENSG00000147364
Uniprot IDs		A0A024RBL3 O60285	A0A024QZ88 Q8TCJ0
PDB IDs
Enriched GO Terms of Interacting Partners?
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