NUAK1 and CASP6

Data Source:
HPRD (in vitro)

		NUAK1	CASP6
Description		NUAK family kinase 1	caspase 6
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Identical Protein Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Adhesion Regulation Of Cell Adhesion Regulation Of Myosin-light-chain-phosphatase Activity Intracellular Signal Transduction Regulation Of Cell Population Proliferation Cellular Response To Glucose Starvation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cellular Senescence	Proteolysis Apoptotic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Cellular Response To Staurosporine Execution Phase Of Apoptosis
Pathways		Regulation of TP53 Activity through Phosphorylation	Apoptotic cleavage of cellular proteins Caspase-mediated cleavage of cytoskeletal proteins Breakdown of the nuclear lamina TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs		Fostamatinib
Diseases
GWAS		Alzheimer's disease biomarkers ( 23419831) Attention function in attention deficit hyperactive disorder ( 26174813) Brain morphology (MOSTest) ( 32665545) General glucose level in pregnancy (gestational week 30-32) ( 30324795) Lateral ventricular volume in normal aging ( 30258056) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Two-hour glucose in pregnancy (gestational week 30-32) ( 30324795)	Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		5 interacting genes: APP CASP6 FBXO25 LATS1 PPP1CC	42 interacting genes: APP CASP10 CASP3 CASP8 CFLAR CHD3 COPS6 DSP EIF2S1 HTT IKBKG KRT18 LMNA LMNB1 LNX1 MAPK6 MAPT NEDD4 NTAQ1 NUAK1 PCYT1A PIN1 PKIA PPL PRKAB2 PRKCZ PSEN1 PSEN2 PSME3 RB1 SATB1 SP1 SRF SRP72 STUB1 TAB1 TFAP2A TOP1 TRAF1 UBE4A UBE4B VIM
Entrez ID		9891	839
HPRD ID		12171	03321
Ensembl ID		ENSG00000074590	ENSG00000138794
Uniprot IDs		A0A024RBL3 O60285	P55212
PDB IDs			1MI9 2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA 4IYR 4N5D 4N6G 4N7J 4N7M 4NBK 4NBL 4NBN 6DEU 6DEV
Enriched GO Terms of Interacting Partners?
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