RAPGEF5 and RAP2B

Data Source:
HPRD (in vitro)

		RAPGEF5	RAP2B
Description		Rap guanine nucleotide exchange factor 5	RAP2B, member of RAS oncogene family
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body	Cytosol Plasma Membrane Bicellular Tight Junction Membrane Specific Granule Membrane Cell-cell Contact Zone Membrane Raft Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTP-dependent Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding
	Biological Process	Small GTPase Mediated Signal Transduction Nervous System Development Regulation Of Catalytic Activity	Signal Transduction Microvillus Assembly Platelet Activation Negative Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Neutrophil Degranulation Regulation Of Protein Tyrosine Kinase Activity Platelet Aggregation Establishment Of Endothelial Intestinal Barrier
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Cutaneous malignant melanoma ( 32341527) Depression in smokers ( 30219690) Dialysis-related mortality ( 21546767) Diastolic blood pressure ( 30224653) Glaucoma ( 30104761) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Night sleep phenotypes ( 27126917) Spatial processing ( 31596458) Squamous cell lung carcinoma ( 28604730) Thyroid stimulating hormone levels ( 17903292) Urinary albumin excretion ( 32277301)	Cerebral amyloid deposition (PET imaging) ( 30361487) Chronotype ( 30696823) Cutaneous melanoma or hair colour ( 32341527) Metabolite levels ( 23823483) PR interval ( 32439900) Serum sulfate level ( 27412988)
Interacting Genes		7 interacting genes: MRAS PLAC9 RAP1A RAP2A RAP2B TMEM253 VANGL1	9 interacting genes: CAMK2B PDE6D RALGDS RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF5 RASSF5 RUNDC3A
Entrez ID		9771	5912
HPRD ID		15208	01548
Ensembl ID		ENSG00000136237	ENSG00000181467
Uniprot IDs		A8MQ07 Q5JPD2 Q92565	P61225
PDB IDs		1WGY	1N4P 1N4Q 1N4R
Enriched GO Terms of Interacting Partners?
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