RAPGEF5 and VANGL1

Data Source:
BioGRID (two hybrid)

		RAPGEF5	VANGL1
Description		Rap guanine nucleotide exchange factor 5	VANGL planar cell polarity protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body	Plasma Membrane Integral Component Of Membrane Lateral Plasma Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTP-dependent Protein Binding	Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Nervous System Development Regulation Of Catalytic Activity	Multicellular Organism Development Pigmentation Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways
Drugs
Diseases			Caudal regression syndrome and Sirenomelia Spina bifida
GWAS		Cutaneous malignant melanoma ( 32341527) Depression in smokers ( 30219690) Dialysis-related mortality ( 21546767) Diastolic blood pressure ( 30224653) Glaucoma ( 30104761) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Night sleep phenotypes ( 27126917) Spatial processing ( 31596458) Squamous cell lung carcinoma ( 28604730) Thyroid stimulating hormone levels ( 17903292) Urinary albumin excretion ( 32277301)	Coronary artery disease ( 33020668) Gut microbiota (bacterial taxa) ( 27694959) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Optic disc size ( 31809533)
Interacting Genes		7 interacting genes: MRAS PLAC9 RAP1A RAP2A RAP2B TMEM253 VANGL1	11 interacting genes: CD82 DVL1 DVL2 DVL3 GMFG LINC00839 NT5C3A RAPGEF5 SMYD3 SRPK1 THAP2
Entrez ID		9771	81839
HPRD ID		15208	18279
Ensembl ID		ENSG00000136237	ENSG00000173218
Uniprot IDs		A8MQ07 Q5JPD2 Q92565	A0A024R0E3 Q8TAA9
PDB IDs		1WGY
Enriched GO Terms of Interacting Partners?
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